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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 06-291 品牌系列 Upstate
商名 - Upstate
描述 Anti-gp130 Antibody 产品信息 格式 Purified 控制 - Positive Control Included: 3T3 Cell Lysate (12-305)
演示 Immunoaffinity Purified immunoglobulin in 0.014M Tris-glycine, pH 7.6, 0.175M NaCl, 0.07% sodium azide) and 30% glycerol 应用 应用 This Anti-gp130 Antibody is validated for use in IP, WB for the detection of gp130. 主要应用 - Western Blotting
生物信息 免疫原品种 GST-tagged fusion protein corresponding to residues Recombinant gst-gp130 containing the cytoplasmic domain (amino acids 713-918) of human gp130 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes gp130. 同种型 IgG 品种反应性 MouseHuman Species Reactivity Note According to a BLAST search, the immunogen has more than 81% homology to human, mouse, dog and rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002184
Entrez基因汇总 The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. 基因符号 - IL-6R-beta
- IL6ST
- CD130
- IL6R-beta
- GP130-RAPS
- GP130
- gp130
- CDw130
纯化方法 Protein A purfied UniProt编号 - P40189
UniProt汇总 FUNCTION: SwissProt: P40189 # Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
SIZE: 918 amino acids; 103523 Da
SUBUNIT: Interacts with INPP5D/SHIP1 (By similarity). Forms heterodimers composed of LIPR and IL6ST (type I OSM receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor).
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
TISSUE SPECIFICITY: Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.
DOMAIN: SwissProt: P40189 The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding. & The box 1 motif is required for JAK interaction and/or activation.
PTM: Phosphorylation of Ser-782 down-regulates cell surface expression.DISEASE:SwissProt: P40189 # Isoform 2 is an autoantigen found in rheumatoid arthritis (RA) but it is not specific to patients with RA.
SIMILARITY: Belongs to the type I cytokine receptor family. Type 2 subfamily. & Contains 5 fibronectin type-III domains. & Contains 1 Ig-like C2-type (immunoglobulin-like) domain.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from mouse 3T3/A31 fibroblasts or human A431 carcinoma cell lysate 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 200 µg
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