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品种反应性 主要应用 宿主 格式 抗体类型 Eq, M, H, R, Ox WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 06-1333 描述 Anti-phospho-TAB1 (Ser438) Antibody Alternate Names - TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
- TGF-beta activated kinase 1/MAP3K7 binding protein 1
- TAK1-binding protein 1
- transforming growth factor beta-activated kinase-binding protein 1
- mitogen-activated protein kinase kinase kinase 7 interacting protein 1
- Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
- 3'-Tab1
- TGF-beta-activated kinase 1-binding protein 1
背景信息 TAK1 binding protein 1 (TAB1) is thought to activate TAK1 MAPKKK in transforming growth factor-beta (TGF-beta) signaling. TAB1 can also associate with TAK1 to form a unique MAPKKK complex that is thought to activate AP-1 and the NFkappaB signaling pathways. Through conformational changes, TAB1 is also thought to induce p38alpha autophosphorylation. It has been linked to both IL-1alpha and TNFalpha signaling and therefore may also be involved in the inflammatory response. Recent research has found that the TAK1-TAB1 complex may have anti-inflammatory effects by aiding stercurensin in regulating the NFκB-dependent inflammatory pathways. 产品信息 格式 Affinity Purified 控制 - Lambda phosphatase untreated and treated RAW264.7 cell lysates
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-phospho-TAB1 (Ser438) Antibody is an antibody against phospho-TAB1 (Ser438) for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human TAB1 when phosphorylated at Ser438. 表位 Phosphorylated Ser438 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes TAB1 when phosphorylated at Ser438. 品种反应性 HorseMouseHumanRatOx Species Reactivity Note Demonstrated to react with mouse. Predicted to react with human, rat, ox, and equine based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_006107
Entrez基因汇总 The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]. 基因符号 - MAP3K7IP
- TAB1
修改 - Phosphorylation
纯化方法 Affinity purified UniProt编号 - Q15750
UniProt汇总 FUNCTION: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
SUBUNIT STRUCTURE: Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2.
TISSUE SPECIFICTY: Ubiquitous.
PTM: Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.
SEQUENCE SIMILARITIES: Contains 1 PP2C-like domain.产品使用声明 质量保证 Evaluated by Western Blot in lambda phosphatase untreated and treated RAW264.7 cell lysates.
Western Blot Analysis: 01 µg/mL of this antibody detected TAB1 on 10 µg of lambda phosphatase untreated and treated RAW264.7 cell lysates.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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