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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 06-1050 描述 Anti-Axin-2 Antibody Alternate Names - Conductin
- Axin-2
- Axin-like protein
- Axil
- Axis inhibition protein 2
背景信息 Axis inhibition protein 2 (Axin-2) has been linked to selective tooth angenesis. It has been found in human thymus, prostate, testis, small intestine, ovarian tissue and in the colon, at a lower expression rate. Axin-2 is involved during skull morphogenesis and missing Axin-2 can cause abnormal skull morphology. Variation in Axin-2 has been associated with accelerated chondrocyte proliferation. 产品信息 格式 Affinity Purified 控制 - SW620 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Axin-2 Antibody detects level of Axin-2 & has been published & validated for use in WB, IH(P). 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: 1:500 dilution from a representative lot detected Axin-2 in colorectal cancer and multiform glioblastoma tissues. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Axin-2. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_004646
Entrez基因汇总 The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq]. 基因符号 - AXIN2
纯化方法 Affinity purified UniProt编号 - Q9Y2T1
UniProt汇总 FUNCTION: Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity).
SUBUNIT STRUCTURE: Interacts with glycogen synthase kinase-3 beta (GSK3B) and beta-catenin. The interaction between axin and beta-catenin occurs via the armadillo repeats contained in beta-catenin (By similarity). Interacts with SMAD7 and RNF111. Interacts with ANKRD6.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Expressed in brain and lymphoblast.
PTM: Probably phosphorylated by GSK3B and dephosphorylated by PP2A (By similarity).
INVOLVEMENT IN DISEASE: Defects in AXIN2 are involved in colorectal cancer (CRC) [MIM:114500]. They appear to be specifically associated with defective mismatch repair.
Defects in AXIN2 are the cause of oligodontia-colorectal cancer syndrome (ODCRCS) [MIM:608615]. Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.
SEQUENCE SIMILARITIES: Contains 1 DIX domain.
Contains 1 RGS domain.产品使用声明 质量保证 Evaluated by Western Blot in SW620 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Axin-2 on 10 µg of SW620 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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