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merck millipore,默克密理博,MAB2013,Anti-K-Cadherin Antibody, extracellular domain, clone 2B6
产品名称：Anti-K-Cadherin Antibody, extracellular domain, clone 2B6
产品型号：MAB2013
Anti-K-Cadherin Antibody, extracellular domain, clone 2B6 detects level of K-Cadherin & has been published & validated for use in WB, IC, IH.
merck millipore,默克密理博,MAB2013,Anti-K-Cadherin Antibody, extracellular domain, clone 2B6
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H IHC, WB, ICC M Purified Monoclonal Antibody 描述 产品目录编号 MAB2013 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-K-Cadherin Antibody, extracellular domain, clone 2B6 Alternate Names - Cadherin-6
背景信息 Cadherins constitute a family of transmembrane glycoproteins involved in Ca2+-dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. The cadherins generally contain five extracellular repeats, a transmembrane domain and a cytoplasmic tail that binds to the catenin family of cytoskeletal anchoring proteins which also function as signal transducers. The extracellular domains are responsible for the specificity of homophilic interactions between cells expressing the same cadherin. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4). Kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins. Cadherin-6 is expressed in the proximal tubule epithelium of the kidney from which most renal cell carcinomas are derived. 产品信息 格式 Purified 演示 Purified immuoglobulin. Liquid in PBS containing 0.09% sodium azide. 应用 应用 Anti-K-Cadherin Antibody, extracellular domain, clone 2B6 detects level of K-Cadherin & has been published & validated for use in WB, IC, IH. 主要应用 - Immunohistochemistry
- Western Blotting
- Immunocytochemistry
应用说明 Western blot: 1:25 - 1:250
Immunohistochemistry: 1:25 - 1:50; Frozen tissue sections with avidin-biotinylated horseradish peroxidase complex (ABC) as the detection method.
Optimal working dilutions must be determined by the end user. I/
生物信息 免疫原品种 Affinity purified extracellular domain of human K-cadherin 表位 extracellular domain 克隆 2B6 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Reacts with the extracellular domain of K-cadherin. 同种型 IgG1 品种反应性 RatHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_004932.2
Entrez基因汇总 This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion. 基因符号 - KCAD
- CDH6
- K-cadherin
UniProt编号 - P55285
UniProt汇总 FUNCTION: SwissProt: P55285 # Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
SIZE: 790 amino acids; 88309 Da
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas.
SIMILARITY: SwissProt: P55285 ## Contains 5 cadherin domains.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at 4°C from date of shipment 包装信息 数量 100 µg
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