merck millipore,默克密理愽
  • merck millipore,默克密理博,05-765,Anti-MLL/HRX Antibody, CT., clone 9-12

  • merck millipore,默克密理博,05-765,Anti-MLL/HRX Antibody, CT., clone 9-12

    产品名称：Anti-MLL/HRX Antibody, CT., clone 9-12
    产品型号：05-765
    Anti-MLL/HRX Antibody, C-term., clone 9-12 is a high quality Mouse Monoclonal Antibody for the detection of MLL/HRX & has been validated in IP, WB, ChIP.

    merck millipore,默克密理博,05-765,Anti-MLL/HRX Antibody, CT., clone 9-12

  • 产品介绍
  • merck millipore,默克密理博,05-765,Anti-MLL/HRX Antibody, CT., clone 9-12

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWB, ChIPMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-765
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-MLL/HRX Antibody, CT., clone 9-12
    背景信息 The acute lymphoblastic leukaemia (ALL)-1 (also known as MLL, HRX, HTRX, and TRX1) gene on human chromosome 11q23 is the site of many locally clustered chromosomal alterations associated with several types of acute leukaemias, including deletions, partial duplications and translocations. Structurally variant proteins derived from the altered gene presumably cause the malignant transformation of early haemopoietic progenitor cells.
    产品信息
    格式 Purified
    控制
    • K562 nuclear extract
    演示 Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
    应用
    应用 Anti-MLL/HRX Antibody, C-term., clone 9-12 is a high quality Mouse Monoclonal Antibody for the detection of MLL/HRX & has been validated in IP, WB, ChIP.
    主要应用
    • Western Blotting
    • Chromatin Immunoprecipitation (ChIP)
    应用说明 Immunoprecipitation: This antibody is reported to immunoprecipitate MLLC from nuclear extracts. The N-terminal fragment, MLLN (300kDa), is also co-immunoprecipitated by this antibody.

    ChIP Analysis: A representative lot of this antibody was used by an independent laboratory for ChIP. See Kuo et al. (2013) and Agherbi, H., et al. (2009) PloS one.4.
    生物信息
    免疫原品种 MBP fusion protein corresponding to residues 3084-3959 of human mixed lineage leukemia (MLL)
    克隆 9-12
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes the C-terminal proteolytic fragment of MLL (MLLC).
    同种型 IgG1
    品种反应性 MouseHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_005933
    基因符号
    • MLL1A
    • MLL
    • HRX
    • CXXC7
    • ALL1
    • HTRX1
    • TRX1
    • FLJ11783
    • ALL-1
    • MLL/GAS7
    • HTRX
    纯化方法 Protein G purfied
    UniProt编号
    • Q03164
    UniProt汇总 FUNCTION: SwissProt: Q03164 # Possibly acts as a transcriptional regulatory factor.
    SIZE: 3969 amino acids; 431764 Da
    SUBUNIT: Interacts with SBF1.
    SUBCELLULAR LOCATION: Nucleus.
    TISSUE SPECIFICITY: Heart, lung, brain and T- and B-lymphocytes.
    DISEASE: SwissProt: Q03164 # Chromosomal aberrations involving MLL are a cause of acute leukemias. Translocation t(1;11)(q21;q23) with MLLT11/AF1Q; translocation t(3;11)(p21;q23) with NCKIPSD/AF3p21; translocation t(3,11)(q25,q23) with GMPS; translocation t(4;11)(q21;q23) with AFF1/MLLT2/AF4; insertion ins(5;11)(q31;q13q23) with AFF4/AF5Q31; translocation t(5;11)(q12;q23) with AF5-alpha/CENPK; translocation t(6;11)(q27;q23) with MLLT4/AF6; translocation t(9;11)(p22;q23) with MLLT3/AF9; translocation t(10;11)(p11.2;q23) with ABI1; translocation t(10;11)(p12;q23) with MLLT10/AF10; t(11;15)(q23;q14) with CASC5 and ZFYVE19; translocation t(11;17)(q23;q21) with MLLT6/AF17; translocation t(11;19)(q23;p13.3) with ELL; translocation t(11;19)(q23;p13.3) with MLLT1/ENL; translocation t(11;19)(q23;p23) with GAS7; translocation t(X;11)(q13;q23) with FOXO4/AFX1. Translocation t(3;11)(q28;q23) with LPP. Translocation t(10;11)(q22;q23) with CXXC6. Translocation t(9;11)(q34;q23) with DAB2IP. Translocation t(4;11)(p12;q23) with FRYL. & A chromosomal aberration involving MLL may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with SEPT11.
    SIMILARITY: SwissProt: Q03164 ## Belongs to the TRX/MLL family. & Contains 3 A.T hook DNA-binding domains. & Contains 1 bromo domain. & Contains 1 CXXC-type zinc finger. & Contains 3 PHD-type zinc fingers. & Contains 1 post-SET domain. & Contains 1 SET domain.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot on in nuclear extract from K562 cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,05-765,Anti-MLL/HRX Antibody, CT., clone 9-12

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