- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 05-582 品牌系列 Upstate
商名 - Upstate
描述 Anti-Herstatin Antibody, clone CW001 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide, before the addition of glycerol to 30% 应用 应用 Detect Herstatin using this Anti-Herstatin Antibody, clone CW001 validated for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
生物信息 免疫原品种 Recombinant human Herstatin corresponding to residues 340-418 克隆 CW001 宿主 Mouse 特异性 Herstatin and Herstatin aggregates 同种型 IgG 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_004448
Entrez基因汇总 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. 基因符号 - HER-2/neu
- ERBB2
- HER2
- HER-2
- NGL
- herstatin
- erbB-2
- C-erbB-2
- NEU
- TKR1
- p185erbB2
纯化方法 Protein G chromatography UniProt编号 - P04626
UniProt汇总 FUNCTION: SwissProt: P04626 # Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF- alpha and amphiregulin.
SIZE: 1255 amino acids; 137910 Da
SUBUNIT: Heterodimer with each of the other ERBB receptors (Potential). Interacts with PRKCABP and PLXNB1. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with MEMO when phosphorylated on Tyr-1248.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
PTM: Ligand-binding increases phosphorylation on tyrosine residues (By similarity).
SIMILARITY: SwissProt: P04626 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by immunoblot using the Herstatin Detection Kit (Catalog #17-354). Previous lots have also been tested with HEK293 cells transfected with Herstatin/HER-2neu 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
上一件merck millipore产品：merck millipore,默克密理博,05-599,Anti-E1A (Ad2/Ad5) Antibody, clone M73
下一件merck millipore产品：merck millipore,默克密理博,71007,NovaTaq™ PCR Master Mix
相关产品
merck millipore,默克密理博,MAB3846,Anti-Heat Shock Protein 70 Antibody, clone 3A3
merck millipore,默克密理博,EZCADP63K,Canine Adiponectin ELISA
merck millipore,默克密理博,05-1312,Anti-Ubiquityl-Histone H2B Antibody, clone 56
merck millipore,默克密理博,399250,NG-Hydroxy-L-arginine, Monoacetate Salt - CAS 53598-01-9 - Calbiochem
merck millipore,默克密理博,05-599,Anti-E1A (Ad2/Ad5) Antibody, clone M73
merck millipore,默克密理博,71007,NovaTaq™ PCR Master Mix
merck millipore,默克密理博,07-500,Anti-p47-phox (mouse) Antibody
merck millipore,默克密理博,AP1160,Anti-NDRG1 Mouse mAb (2D7)
merck millipore,默克密理博,496915,Oridonin, R. rubescens - CAS 28957-04-2 - Calbiochem