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merck millipore,默克密理博,496915,Oridonin, R. rubescens - CAS 28957-04-2 - Calbiochem
产品名称：Oridonin, R. rubescens - CAS 28957-04-2 - Calbiochem
产品型号：496915
A cell-permeable diterpenoid compound that possesses anti NF-κB activity and displays antiproliferative and antiangiogenic properties.
merck millipore,默克密理博,496915,Oridonin, R. rubescens - CAS 28957-04-2 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₀H₂₈O₆ 28957-04-2 描述 概述 A cell-permeable diterpenoid compound that possesses anti NF-κB activity and displays antiproliferative (ED50 = ~ 2.7 µg/ml in lymphoid malignant cells) and antiangiogenic properties (significantly inhibits network formation of HMEC-1 cells at 2.5 µg/ml). Reported to affect DNA synthesis, induce apoptosis and initiate cell cycle arrest. Shown to efficiently block both TNF-α and LPS-induced NF-κB activity in Jurkat and in RAW264.7 murine macrophages, and inhibit p65 NF-κB transcriptional activity (IC50 = ~ 5 µg/ml in MT-1 cells) by disrupting NF-κB DNA-binding activity without interfering with its nuclear translocation. 产品目录编号 496915 品牌系列 Calbiochem®
参考 参考 Ikezoe, T., et al. 2005. Mol. Cancer Ther. 4, 578.
Meade-Tollin, L.C., et al. 2004. J. Nat. Prod. 67, 2.产品信息 CAS号 28957-04-2 具有ATP竞争性 N 形式 Yellow solid Hill配方 C₂₀H₂₈O₆ 化学配方 C₂₀H₂₈O₆ Molar Mass 364.4 可逆 N 结构配方图像 生物信息 主靶 NF-κB transcriptional activity 主靶IC50 5 µg/ml inhibiting p65 NF-κB transcriptional activity in MT-1 cells 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO GHS安全信息 RTECS NZ8177000 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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