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品种反应性 主要应用 宿主 格式 抗体类型 M, H IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 05-579 品牌系列 Upstate
商名 - Upstate
描述 Anti-Endostatin Antibody, clone 1837.46 产品信息 格式 Purified 演示 50mM sodium phosphate, pH 8.0, 0.05% sodium azide, before the addition of glycerol to 30% 应用 应用 Anti-Endostatin Antibody, clone 1837.46 is an antibody against Endostatin for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
生物信息 免疫原品种 Full-length recombinant murine endostatin 克隆 clone 1837.46 宿主 Mouse 特异性 endostatin 同种型 IgG 品种反应性 MouseHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_009929
Entrez基因汇总 This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Two transcript variants encoding different isoforms have been found for this gene. 基因符号 - FLJ27325
- COL18A1
- MGC74745
- endostatin
- KNO
纯化方法 Thiophilic chromatography UniProt编号 - P39060
UniProt汇总 FUNCTION: SwissProt: P39060 # Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
SIZE: 1754 amino acids; 178160 Da
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
TISSUE SPECIFICITY: Present in multiple organs with highest levels in liver, lung and kidney.
PTM: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
DISEASE: SwissProt: P39060 # Defects in COL18A1 are a cause of Knobloch syndrome (KNO) [MIM:267750]. KNO is an autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.
SIMILARITY: SwissProt: P39060 ## Belongs to the multiplexin collagen family. & Contains 1 FZ (frizzled) domain. & Contains 1 TSP N-terminal (TSPN) domain.产品使用声明 质量保证 routinely evaluated by immunoblot on 3T3 cell lysates 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µL
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