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品种反应性 主要应用 宿主 格式 抗体类型 R, H WB M Purified Monoclonal Antibody 描述 产品目录编号 05-502 品牌系列 Upstate
商名 - Upstate
描述 Anti-FRS2/SNT-1 Antibody 产品信息 格式 Purified 演示 0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide containing 30% glycerol 应用 应用 Detect FRS2/SNT-1 using this Anti-FRS2/SNT-1 Antibody validated for use in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Peptide corresponding to residues 283-297 of human FRS2/SNT-1 宿主 Mouse 特异性 FRS2/SNT-1 in unstimulated cells and phosphorylated FRS2/SNT-1 in NGF-stimulated cells 同种型 IgG 品种反应性 RatHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_006654
基因符号 - FRS2alpha
- FRS2
- SNT1
- FRS2A
- SNT-1
- SNT
纯化方法 Protein G chromatography UniProt编号 - Q8WU20
UniProt汇总 FUNCTION: SwissProt: Q8WU20 # Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
SIZE: 512 amino acids; 57528 Da
SUBUNIT: Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine- phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.
SUBCELLULAR LOCATION: Intracytoplasmic membrane. Note=Cytoplasmic, membrane-bound.
TISSUE SPECIFICITY: Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
PTM: Phosphorylated on tyrosine residues upon stimulation by NGF. & Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination (By similarity).
SIMILARITY: SwissProt: Q8WU20 ## Contains 1 IRS-type PTB domain.产品使用声明 质量保证 routinely evaluated by immunoprecipitating FRS2/SNT-1 from NGF-stimulated and unstimulated rat PC-12 RIPA cell lysates, subsequently immunoblotted with the same antibody. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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