merck millipore,默克密理愽
  • merck millipore,默克密理博,344092,Formin FH2 Domain Inhibitor, SMIFH2 - CAS 340316-62-3 - Calbiochem

  • merck millipore,默克密理博,344092,Formin FH2 Domain Inhibitor, SMIFH2 - CAS 340316-62-3 - Calbiochem

    产品名称：Formin FH2 Domain Inhibitor, SMIFH2 - CAS 340316-62-3 - Calbiochem
    产品型号：344092
    The Formin FH2 Domain Inhibitor, SMIFH2, also referenced under CAS 340316-62-3, controls the biological activity of Formin FH2 Domain. This small molecule/inhibitor is primarily used for Membrane appl More>>

    merck millipore,默克密理博,344092,Formin FH2 Domain Inhibitor, SMIFH2 - CAS 340316-62-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,344092,Formin FH2 Domain Inhibitor, SMIFH2 - CAS 340316-62-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₅H₉BrN₂O₃S340316-62-3
    描述
    概述 A cell-permeable thiooxodihydropyrimidinedione compound that inhibits both formin-mediated, profilin-independent actin nucleation (IC50 ~15 µM using mDia1 or mDia2) and formin-mediated elongation of actin filaments in the presence of profilin (IC50 ~4 µM using Cdc12 or mDia2), but not the Arp2/3-mediated or formin-independent actin assembly. SMIFH2 targets the FH2 (formin homology 2) domain of formins from a large variety of species, including murine mDia1/2, C. elegans CYK-1, S. pombe Cdc12, S. pombe Fus1, and S. cerevisiae Bni1, and decreases formin affinity for the actin filament barbed end. SMIFH2, at 25 µM, is shown to selectively disrupt formin-dependent actin cables and contractile rings, but not Arp2/3-dependent, CK-666- (Cat. No. 182515) sensitive actin patches, in fission yeast. SMIFH2 is also demonstrated to affect F-actin cytoskeleton structures and cell migration (by a 2-fold decrease at 10 µM) in NIH 3T3 fibroblast cultures.
    产品目录编号 344092
    品牌系列 Calbiochem®
    同义词 Small Molecule Inhibitor of Formin Homology 2 domain, 1-(3-Bromophenyl)-5-(2-furylmethylene)-2-thioxo-hexahydropyrimidine-4,6-dione, Actin Assembly Inhibitor XV
    参考
    参考 Rizvi, S.A., et al. 2009. Chem. Biol. 16, 1158.
    产品信息
    CAS号 340316-62-3
    形式 Off-white to beige solid
    Hill配方 C₁₅H₉BrN₂O₃S
    化学配方 C₁₅H₉BrN₂O₃S
    Molar Mass 377.2
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC (sum of two geometrical isomers)
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Use only fresh DMSO. Following reconstiution, aliquot an freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,344092,Formin FH2 Domain Inhibitor, SMIFH2 - CAS 340316-62-3 - Calbiochem

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