merck millipore,默克密理博,480065,Necrostatin-1 - CAS 4311-88-0

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

当前位置：首页 > >Merck Millipore > 生命科学研究
生命科学研究

merck millipore,默克密理博,480065,Necrostatin-1 - CAS 4311-88-0 - Calbiochem
产品名称：Necrostatin-1 - CAS 4311-88-0 - Calbiochem
产品型号：480065
A cell-permeable, potent, and selective blocker of necroptosis, a nonapoptotic necrotic cell death pathway mediated by DRs that offers neuroprotection in a murine model of ischemic brain injury.

merck millipore,默克密理博,480065,Necrostatin-1 - CAS 4311-88-0 - Calbiochem

产品介绍

merck millipore,默克密理博,480065,Necrostatin-1 - CAS 4311-88-0 - Calbiochem

重要规格表

经验配方	CAS号
C₁₃H₁₃N₃OS	4311-88-0

描述
概述	A cell-permeable, potent, and selective blocker of necroptosis (EC₅₀ = 494 nM in FADD-deficient Jurkat cells treated with TNF-α), a nonapoptotic necrotic cell death pathway mediated by death-domain receptors (DRs) that offers neuroprotection in a murine model of ischemic brain injury. Exhibits no effect on DR-induced apoptosis. Also acts as a selective and ATP-competitive inhibitor of RIP1 kinase with negligible effect of RIP2 kinase activity. Nec-1 target appears to be a critical common necroptotic step upstream of execution events and downstream of DRs. Inactive control, Nec-1i, is also available (Cat. No. 480066). Also available as a 25 mM solution in DMSO (Cat. No. 505224).
产品目录编号	480065
品牌系列	Calbiochem®
同义词	Necrosome Inhibitor I, 5-(Indol-3-ylmethyl)-(2-thio-3-methyl)hydantoin, Nec-1, Nec1, RIP1 Inhibitor I, Methyl-thiohydantoin-tryptophan, MTH-Trp, Receptor-Interacting Protein 1 Inhibitor I, RIPK 1 Inhibitor I, Necrosis Inhibitor II

参考
参考	Degterev, A., et al. 2013. Nat. Chem. Biol. 9, 192. Degterev, A., et al. 2012. Cell Death Differ. 20, 366. Christofferson, D.E., et al. 2012. Cell Death Dis. 3, e320. Takahashi, N., et al. 2012. Cell Death Dis. 3, e437. Degterev, A., et al. 2008. Nat. Chem. Biol. 4, 313. Degterev, A., et al. 2005. Nat. Chem. Biol. 1, 112. Muller, A.J., et al. 2005. Nat. Med. 11, 312. Teng, X., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5039.

参考

Degterev, A., et al. 2013. Nat. Chem. Biol. 9, 192.
Degterev, A., et al. 2012. Cell Death Differ. 20, 366.
Christofferson, D.E., et al. 2012. Cell Death Dis. 3, e320.
Takahashi, N., et al. 2012. Cell Death Dis. 3, e437.
Degterev, A., et al. 2008. Nat. Chem. Biol. 4, 313.
Degterev, A., et al. 2005. Nat. Chem. Biol. 1, 112.
Muller, A.J., et al. 2005. Nat. Med. 11, 312.
Teng, X., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5039.

产品信息
CAS号	4311-88-0
具有ATP竞争性	Y
形式	Yellow crystalline solid
Hill配方	C₁₃H₁₃N₃OS
化学配方	C₁₃H₁₃N₃OS
Molar Mass	259.3
可逆	N
结构配方图像

生物信息
主靶	Blocker of necroptosis
主靶IC₅₀	EC50 = 494 nM in blocking necrosis in FADD-deficient Jurkat cells treated with TNF-α
纯度	≥95% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO or MeOH

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.