merck millipore,默克密理愽
  • merck millipore,默克密理博,21-169,FOPflash (mutant TCF binding sites)

  • merck millipore,默克密理博,21-169,FOPflash (mutant TCF binding sites)

    产品名称：FOPflash (mutant TCF binding sites)
    产品型号：21-169
    Transfection grade T cell factor (TCF) reporter plasmid containing 2 full & oneincomplete copy of the Tcf binding site (mutated) followed by 3 copies in the reverse orientation. Serves as a nega More>>

    merck millipore,默克密理博,21-169,FOPflash (mutant TCF binding sites)

  • 产品介绍
  • merck millipore,默克密理博,21-169,FOPflash (mutant TCF binding sites)

    描述
    产品目录编号 21-169
    品牌系列 Upstate
    商名
    • Upstate
    描述 FOPflash (mutant TCF binding sites)
    应用
    应用 Transfection grade T cell factor (TCF) reporter plasmid containing 2 full & one
    incomplete copy of the Tcf binding site (mutated) followed by 3 copies in the reverse orientation. Serves as a negative control to TOPflash.
    主要应用
    • Transfection
    生物信息
    Entrez基因编号
    • NM_000545.4
    Entrez基因汇总 This gene encodes transcription factor 4, a basic helix-turn-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is expressed predominantly in pre-B-cells, although it is found in other tissues as well. Multiple alternatively spliced transcript variants that encode different proteins have been described.
    基因符号
    • HNF1a
    • TCF1
    • MODY3
    • HNF1
    • HNF-1A
    • TCF-1
    • HNF1A
    • LFB1
    UniProt编号
    • P15884
    • P20823
    • P15923
    UniProt汇总 FUNCTION: SwissProt: P20823 # Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
    SIZE: 631 amino acids; 67356 Da
    SUBUNIT: Binds DNA as a dimer.
    SUBCELLULAR LOCATION: Nucleus.
    TISSUE SPECIFICITY: Liver.
    DISEASE: SwissProt: P20823 # Defects in HNF1A may predispose to hepatic adenomas [MIM:142330]. Hepatic adenomas are benign tumors at risk of malignant transformation. Bi-allelic inactivation of HNF1A, whether sporadic or associated with MODY3, may be an early step in the developmant of some hepatocellular carcinomas. & Defects in HNF1A are the cause of maturity onset diabetes of the young type 3 (MODY3) [MIM:600496]; also symbolized MODY-3. MODY [MIM:606391] is a form of diabetes characterized by an autosomal dominant mode of inheritance, age of onset of 25 years or younger and a primary defect in insulin secretion. The clinical phenotype of MODY3 is characterized by severe insulin secretory defects, and by major hyperglycemia associated with microvascular complications. & Defects in HNF1A are a cause of susceptibility to insulin-dependent diabetes mellitus (IDDM) [MIM:222100].
    SIMILARITY: SwissProt: P20823 ## Belongs to the HNF1 homeobox family. & Contains 1 homeobox DNA-binding domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 5 µg

    merck millipore,默克密理博,21-169,FOPflash (mutant TCF binding sites)

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