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merck millipore,默克密理博,05-547,Anti-phospho-PP2A Antibody, C subunit (Tyr307), clone 4B10
产品名称：Anti-phospho-PP2A Antibody, C subunit (Tyr307), clone 4B10
产品型号：05-547
Anti-phospho-PP2A Antibody, C subunit (Tyr307), clone 4B10 detects level of phospho-PP2A & has been published & validated for use in ELISA.
merck millipore,默克密理博,05-547,Anti-phospho-PP2A Antibody, C subunit (Tyr307), clone 4B10
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Vrt ELISA M Ascites Monoclonal Antibody 描述 产品目录编号 05-547 品牌系列 Upstate
商名 - Upstate
描述 Anti-phospho-PP2A Antibody, C subunit (Tyr307), clone 4B10 产品信息 格式 Ascites 演示 mouse ascites containing 30% glycerol and 0.05% azide 应用 应用 Anti-phospho-PP2A Antibody, C subunit (Tyr307), clone 4B10 detects level of phospho-PP2A & has been published & validated for use in ELISA. 主要应用 - ELISA
应用说明 Not recommended for WB. 生物信息 免疫原品种 Peptide corresponding to residues 302-309 of human PP2A; recognizes phosphorylated PP2A on tyrosine 307. 克隆 4B10 宿主 Mouse 特异性 PP2A phosphorylated on tyrosine 307 同种型 IgG1 品种反应性 Vertebrates 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_004156
Entrez基因汇总 This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. 基因符号 - RP-C
- PPP2CA
- PP2CA
- PP2A-alpha
- PP2Ac
修改 - Phosphorylation
纯化方法 Ascites UniProt编号 - P67775
UniProt汇总 FUNCTION: SwissProt: P67775 # PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Can dephosphorylate SV40 large T antigen and p53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen.
COFACTOR: Binds 1 iron ion per subunit (By similarity). & Binds 1 manganese ion per subunit (By similarity).
SIZE: 309 amino acids; 35594 Da
SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
SUBCELLULAR LOCATION: Cytoplasm.
PTM: Reversibly methyl esterified on Leu-309. Carboxyl methylation may play a role in holoenzyme assembly. It varies during the cell cycle. & Phosphorylation of either threonine (by autophosphorylation- activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.
SIMILARITY: SwissProt: P67775 ## Belongs to the PPP phosphatase family. PP-1 subfamily.产品使用声明 质量保证 routinely evaluated by ELISA 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 100 µL
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