merck millipore,默克密理愽
  • merck millipore,默克密理博,05-533,Anti-phospho-CaM Kinase II Antibody, α subunit, (Thr286), clone 22B1

  • merck millipore,默克密理博,05-533,Anti-phospho-CaM Kinase II Antibody, α subunit, (Thr286), clone 22B1

    产品名称：Anti-phospho-CaM Kinase II Antibody, α subunit, (Thr286), clone 22B1
    产品型号：05-533
    Detect phospho-CaM Kinase II using this Anti-phospho-CaM Kinase II Antibody, α subunit, (Thr286), clone 22B1 validated for use in WB.

    merck millipore,默克密理博,05-533,Anti-phospho-CaM Kinase II Antibody, α subunit, (Thr286), clone 22B1

  • 产品介绍
  • merck millipore,默克密理博,05-533,Anti-phospho-CaM Kinase II Antibody, α subunit, (Thr286), clone 22B1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-533
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-CaM Kinase II Antibody, α subunit, (Thr286), clone 22B1
    产品信息
    格式 Purified
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 Detect phospho-CaM Kinase II using this Anti-phospho-CaM Kinase II Antibody, α subunit, (Thr286), clone 22B1 validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Peptide corresponding to residuues 281-294 of rat Cam Kinase II alpha-subunit; recognizes phosphorylated CaM Kinase II on Threonine 286
    克隆 22B1
    宿主 Mouse
    特异性 phospho-CaM Kinase II α subunit
    同种型 IgG1
    品种反应性 Rat
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_015981 and others
    Entrez基因汇总 The product of this gene belongs to the Serine/Threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This enzyme is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene.
    基因符号
    • CAMKA
    • CAMK2A
    • KIAA0968
    修改
    • Phosphorylation
    纯化方法 Protein G chromatography
    UniProt编号
    • Q9UQM7
    UniProt汇总 FUNCTION: SwissProt: Q9UQM7 # CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
    SIZE: 478 amino acids; 54030 Da
    SUBUNIT: CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC, MPDZ, SYN1 and SYNGAP1 (By similarity).
    SUBCELLULAR LOCATION: Cell junction, synapse, presynaptic cell membrane (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic lipid rafts (By similarity).
    SIMILARITY: SwissProt: Q9UQM7 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on rat brain microsomal protein preparation
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-533,Anti-phospho-CaM Kinase II Antibody, α subunit, (Thr286), clone 22B1

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