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描述 产品目录编号 ALP60-100UG 品牌系列 Chemicon®
商名 - Chemicon
描述 Apolipoprotein C-III, human 概述 MOLECULAR WEIGHT:
8,750Alternate Names - ApoCIII
背景信息 The physiological role of Apo CIII is unknown. It is suggested that Apo CIII may inhibit the activation of lipoprotein lipase by Apo CII. 产品信息 演示 Liquid in 10 mM NH4HCO3, pH 7.4. 应用 主要应用 - Positive Control
生物信息 纯度 > 95% by SDS-PAGE 来源 Human plasma tested negative for HBsAg and HIV-I, HIV-II, HBc and Hepatitis C antibodies. All blood products should be treated as potentially infectious. 品种 Human Entrez基因编号 - NM_000040.1
Entrez基因汇总 Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. 基因符号 - MGC150353
- APOC3
- ApoC-III
- Apo-CIII
- APOCIII
UniProt编号 - P02656
UniProt汇总 FUNCTION: SwissProt: P02656 # Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.
SIZE: 99 amino acids; 10852 Da
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.
PTM: O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues.
DISEASE:SwissProt: P02656 # Defects in APOC3 may be a cause of hyperalphalipoproteinemia [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).
SIMILARITY: SwissProt: P02656 ## Belongs to the apolipoprotein C3 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20ºC or below in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. All blood products should be treated as potentially infectious. 包装信息 数量 100 µg
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