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品种反应性 主要应用 宿主 格式 抗体类型 R FC M Purified Monoclonal Antibody 描述 产品目录编号 05-468 品牌系列 Upstate
商名 - Upstate
描述 Anti-FcεRI α subunit Antibody 产品信息 格式 Purified 演示 0.1M Tris-glycine, 0.15M NaCl, 0.05% sodium azide prior to the addition of glycerol to 30% 应用 应用 Anti-FcεRI α subunit Antibody is an antibody against FcεRI α subunit for use in FC & IP. 主要应用 - Flow Cytometry
应用说明 Western blot is not recommended 生物信息 免疫原品种 Whole rat basophilic leukemia cells, positive for the rat high-affinity receptor recognizing immunoglobulin E (FcεRI). 宿主 Mouse 特异性 FcεRIα 同种型 IgG1κ 品种反应性 Rat 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002001
Entrez基因汇总 The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139); only the alpha subunit is glycosylated.[supplied by OMIM] 基因符号 - FCE1A
- FCER1A
- FcERI
纯化方法 Protein G chromatography UniProt编号 - P12319
UniProt汇总 FUNCTION: SwissProt: P12319 # Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
SIZE: 257 amino acids; 29596 Da
SUBUNIT: Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P12319 ## Contains 2 Ig-like (immunoglobulin-like) domains.产品使用声明 质量保证 routinely evaluated by immunoprecipitation of rat FcεRIα from biotinylated rat basophilic leukemia cell lysate 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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