merck millipore,默克密理愽
  • merck millipore,默克密理博,05-1921,Anti-phospho IRS1 (Ser522) Antibody, clone 17.5.2

  • merck millipore,默克密理博,05-1921,Anti-phospho IRS1 (Ser522) Antibody, clone 17.5.2

    产品名称：Anti-phospho IRS1 (Ser522) Antibody, clone 17.5.2
    产品型号：05-1921
    This phospho IRS1 antibody is validated for use in WB for the detection of the phospho IRS1 protein.

    merck millipore,默克密理博,05-1921,Anti-phospho IRS1 (Ser522) Antibody, clone 17.5.2

  • 产品介绍
  • merck millipore,默克密理博,05-1921,Anti-phospho IRS1 (Ser522) Antibody, clone 17.5.2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-1921
    描述 Anti-phospho IRS1 (Ser522) Antibody, clone 17.5.2
    Alternate Names
    • Insulin Receptor Substrate 1
    背景信息 IRS1 (Insulin Receptor Substrate 1) transmits insulin signals via metabolic and mitogenic pathways. IRS1 is heavily phosphorylated on both serine and tyrosine residues. These phosphorylated tyrosines enable IRS to act as a docking protein that binds SH2 domains of such proteins as PI3 Kinase (phosphatidylinositol 3-kinase) and GRB2, resulting in activation. Over expression and phosphorylation of serine is associated with insulin resistance and breast cancer. Some of the more notable phosphorylation sites are Ser302 that is phosphorylated following insulin stimulation. Ser307, phosphorylated by JNK and IKK, is a key regulatory site that appears to disrupt the IRS1/IR interaction and inhibits insulin-mediated activation of the PI3 kinase and MAPK pathways, and Ser636/639 that is known to be phosphorylated by p70S6K downstream of mTOR and acts as a negative feedback loop.
    产品信息
    格式 Purified
    控制
    • Calyculin/Okadaic Acid treated and untreated CHO-IR/IRS1 cell lysates
    演示 Purified mouse monoclonal IgG3κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) without 0.05% sodium azide.
    应用
    应用 This phospho IRS1 antibody is validated for use in WB for the detection of the phospho IRS1 protein.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to rat IRS1 phosphorylated at Ser522.
    表位 Ser522
    克隆 17.5.2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes IRS1 phosphorylated at Ser522.
    同种型 IgG3κ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human and rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_034700
    Entrez基因汇总 IRS1 (Insulin Receptor Substrate 1) transmits insulin signals via metabolic and mitogenic pathways. IRS1 is heavily phosphorylated on both serine and tyrosine residues. These phosphorylated tyrosines enable IRS to act as a docking protein that binds SH2 domains of such proteins as PI3 Kinase (phosphatidylinositol 3-kinase) and GRB2, resulting in activation. Over expression and phosphorylation of serine is associated with insulin resistance and breast cancer. Some of the more notable phosphorylation sites are Ser302 that is phosphorylated following insulin stimulation. Ser307, phosphorylated by JNK and IKK, is a key regulatory site that appears to disrupt the IRS1/IR interaction and inhibits insulin-mediated activation of the PI3 kinase and MAPK pathways, and Ser636/639 that is known to be phosphorylated by p70S6K downstream of mTOR and acts as a negative feedback loop.
    基因符号
    • IRS-1
    • HIRS-1
    纯化方法 Protein G purfied
    UniProt编号
    • P35569
    UniProt汇总 FUNCTION: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor it binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. Interacts with SOCS7 By similarity.

    SUBUNIT STRUCTURE: Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR via the PTB domain. Binds to phosphatidylinositol 3-kinase p85 subunit via the phosphorylated YXXM motifs. Binds ROCK1 By similarity. Binds to UBTF and PIK3CA in nuclear extracts.

    TISSUE SPECIFICTY: Expressed in osteoblasts, but not in osteoclasts.

    PTM: Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-307 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor by similarity.

    Phosphorylation of Tyr-891 is required for GRB2-binding By similarity.

    SEQUENCE SIMILARITIES: Contains 1 IRS-type PTB domain.

    Contains 1 PH domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in Calyculin/Okadaic Acid treated and untreated CHO-IR/IRS1 cell lysates.

    Western Blot Analysis: 0.1 µg/mL of this antibody detected IRS1 on 10 µg of Calyculin/Okadaic Acid treated and untreated CHO-IR/IRS1 cell lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-1921,Anti-phospho IRS1 (Ser522) Antibody, clone 17.5.2

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