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品种反应性 主要应用 宿主 格式 抗体类型 M, H IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 05-1583 描述 Anti-PRL-2 Antibody, clone 42 Alternate Names - protein tyrosine phosphatase type IVA, member 2
- Protein-tyrosine phosphatase 4a2
- Protein-tyrosine phosphatase of regenerating liver 2
- phosphatase of regenerating liver 2
- protein tyrosine phosphatase IVA
- protein tyrosine phosphatase IVA2
背景信息 PRL-2 is one of three members (PRL-1, PRL-2, and PRL-3) that is part of a unique protein-tyrosine phosphatase ((PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP is known to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferres a transformed phenotype and can result in a tumor growth in nude mice, suggesting a role in tumorigenesis. Alternatively spliced transcript variants that encode two distinct isoforms have been described 产品信息 格式 Purified 控制 - HeLa cell lysate
演示 Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 Anti-PRL-2 Antibody, clone 42 detects level of PRL-2 & has been published & validated for use in WB, IH & IP. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis:
A representative lot was used by an independent laboratory in IH.
Immunoprecipitation Analysis:
A representative lot was used by an independent laboratory in IP.生物信息 免疫原品种 GST-tagged recombinant protein corresponding to mouse PRL-2. 表位 Unknown 克隆 42 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes PRL-2. 同种型 IgG2bκ 品种反应性 MouseHuman Species Reactivity Note Demonstrated to react with human. Predicted to react with mouse based on 100% sequence homology. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001158217.1
基因符号 - ptp-IV1b
- ptp4a2
- HH13
- HH7-2
- HU-PP-1
- OV-1
- PRL-2
- PRL2
- PTP(CAAXII)
- PTP4A
- PTPCAAX2
- ptp-IV1a
纯化方法 Protein G purfied UniProt编号 - O70274
UniProt汇总 FUNCTION: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Inhibits geranylgeranyltransferase type II activity by blocking the association between RABGGTA and RABGGTB By similarity.
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
ENZYME REGULATION: Inhibited by sodium orthovanadate and pentamidine By similarity.
SUBUNIT STRUCTURE: In contrast to PTP4A1 and PTP4A3, does not interact with tubulin. Interacts with RABGGTB By similarity.
SUBCELLULAR LOCATION: Cell membrane. Early endosome. Cytoplasm
TISSUE SPECIFICTY: Expressed in skeletal muscle, and at lower levels in liver, lung, heart, kidney, brain, testis and spleen. Ref.1
PTM: Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB By similarity.
SEQUENCE SIMILARITIES: Belongs to the protein-tyrosine phosphatase family.
Contains 1 tyrosine-protein phosphatase domain.产品使用声明 质量保证 Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 0.5 µg/ml of this antibody detected PRL-2 on 10 µg of HeLa cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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