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merck millipore,默克密理博,05-117,Anti-FGF-2/basic FGF (neutralizing) Antibody, clone bFM-1
产品名称：Anti-FGF-2/basic FGF (neutralizing) Antibody, clone bFM-1
产品型号：05-117
Anti-FGF-2/basic FGF (neutralizing) Antibody, clone bFM-1 is an antibody against FGF-2/basic FGF (neutralizing) for use in NEUT, RIA.
merck millipore,默克密理博,05-117,Anti-FGF-2/basic FGF (neutralizing) Antibody, clone bFM-1
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, B, H, M RIA, NEUT M Purified Monoclonal Antibody 描述 产品目录编号 05-117 品牌系列 Upstate
商名 - Upstate
描述 Anti-FGF-2/basic FGF (neutralizing) Antibody, clone bFM-1 Alternate Names - heparin-binding growth factor 2.
- Basic fibroblast growth factor
- basic fibroblast growth factor bFGF
- fibroblast growth factor 2
- fibroblast growth factor 2 (basic)
背景信息 Basic fibroblast growth factor, also known as bFGF or FGF2, is a member of the fibroblast growth factor family.
In normal tissue, basic fibroblast growth factor is present in basement membranes and in the subendothelial extracellular matrix of blood vessels. It stays membrane-bound as long as there is no signal peptide.
It has been hypothesized that, during both wound healing of normal tissues and tumor development, the action of heparan sulfate-degrading enzymes activates bFGF, thus mediating the formation of new blood vessels, a process known as angiogenesis.
Additionally, bFGF is a critical component of human embryonic stem cell culture medium; the growth factor is necessary for the cells to remain in an undifferentiated state, although the mechanisms by which it does this are poorly defined.产品信息 格式 Purified 控制 - Fetal liver or kidney tissue.
演示 Purified mouse monoclonal IgG1κ in TBS. Protein determined by a Bradford microtiter assay using mouse IgG as the standard. Frozen solution. 应用 应用 Anti-FGF-2/basic FGF (neutralizing) Antibody, clone bFM-1 is an antibody against FGF-2/basic FGF (neutralizing) for use in NEUT, RIA. 主要应用 - Radioimmunoassay
- Neutralizing
不建议的应用 - Western Blotting
生物信息 免疫原品种 Purified bovine brain basic FGF (HBGF-2). Clone bFM-1. 表位 a.a. 5-24 克隆 bFM-1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes the non-denatured form of FGF-2/basic FGF; does not cross-react with bovine acidic FGF. 同种型 IgG1κ 品种反应性 RatBovineHumanMouse Species Reactivity Note This antibody is highly specific for the non-denatured form of FGF-2/basic FGF from bovine, human, rat and mouse sources. Does not cross-react with bovine acidic FGF. 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002006.3
Entrez基因汇总 The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. 基因符号 - FGFB
- FGF2
- Prostatropin
- BFGF
- prostatropin
- HBGF-2
纯化方法 Ammonium sulfate precipitation and DEAE-cellulose chromatography UniProt编号 - P09038
UniProt汇总 FUNCTION: SwissProt: P09038 # The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.
SIZE: 155 amino acids; 17254 Da
SUBUNIT: Monomer. Interacts with CSPG4 and FGFBP1. Found in a complex with FGFBP1, FGF1 and FGF2.
SIMILARITY: SwissProt: P09038 ## Belongs to the heparin-binding growth factors family.
MISCELLANEOUS: This protein binds heparin more strongly than does aFGF. ... hide » see more »产品使用声明 质量保证 Routinely evaluated by neutralization of greater than 50% of growth of FBHE cells simulated with FGF-2/bFGF.
Neutralization of bFGF Activity Assay:
2.5 µg/mL of this lot of antibody neutralized greater than 40% of growth of FBHE cells simulated with 5 ng/mL of FGF-2/bFGF.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20ºC from date of receipt. Aliquot to avoid repeated freezing and thawing. For maximum recovery of the product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 500 µg
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