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merck millipore,默克密理博,AB3549P,Anti-Monocarboxylate Transporter 8 Antibody
产品名称：Anti-Monocarboxylate Transporter 8 Antibody
产品型号：AB3549P
Anti-Monocarboxylate Transporter 8 Antibody is an antibody against Monocarboxylate Transporter 8 for use in ELISA & WB.
merck millipore,默克密理博,AB3549P,Anti-Monocarboxylate Transporter 8 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M WB, ELISA Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB3549P Replaces AB3324P 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Monocarboxylate Transporter 8 Antibody Alternate Names - X-linked PEST-containing Transporter
- MCT8
背景信息 MCT8 is an integral membrane protein that is associated with the plasma membrane. A member of the Major Facilitator Superfamily, MCT8 serves as a proton-linked monocarboxylate transporter that catalyzes the rapid transport of monocarboxylates and ketone bodies across the plasma membrane. Expression of MCT8 is greatest in liver and kidney. 产品信息 格式 Affinity Purified 控制 - POSITIVE CONTROL: Liver or kidney extracts
演示 Affinitypurified immunoglobulin presented as a liquid in PBS with 0.1% BSA. 应用 应用 Anti-Monocarboxylate Transporter 8 Antibody is an antibody against Monocarboxylate Transporter 8 for use in ELISA & WB. 主要应用 - Western Blotting
- ELISA
应用说明 Western blot: 1-5 μg/mL using ECL.
ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide (Catalog number AG202) per well.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 A 19 amino acid peptide sequence within the cytoplasmic, C-terminus of mouse MCT8. The immunogen sequence is 94% conserved in rat and 89% in human MCT8 and shows no significant sequence homology with other MCT family members. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes mouse Monocarboxylate Transporter 8. 品种反应性 Mouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_006517.2
基因符号 - MCT7
- SLC16A2
- DXS128E
- DXS128
- MCT8
- AHDS
- XPCT
UniProt编号 - P36021
UniProt汇总 FUNCTION: SwissProt: P36021 # Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr (By similarity).
SIZE: 539 amino acids; 59511 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
TISSUE SPECIFICITY: Highly expressed in liver and heart.
DISEASE: SwissProt: P36021 # Defects in SLC16A2 are the cause of monocarboxylate transporter 8 deficiency (MCT8 deficiency) [MIM:300523]. MCT8 deficiency consists of a severe form of X-linked psychomotor retardation combined with abnormal thyroid hormone (TH) levels. Thyroid hormone deficiency can be caused by defects of hormone synthesis and action, but it has also been linked to a defect in cellular hormone transport. Affected patients are males with abnormal relative concentrations of three circulating iodothyronines, as well as severe neurological abnormalities, including global developmental delay, central hypotonia, spastic quadriplegia, dystonic movements, rotary nystagmus, and impaired gaze and hearing. Heterozygous females had a milder thyroid phenotype and no neurological defects.
SIMILARITY: SwissProt: P36021 ## Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µg
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