merck millipore,默克密理愽
  • merck millipore,默克密理博,04-921,Anti-GluR6/7 Antibody, clone NL9, rabbit monoclonal

  • merck millipore,默克密理博,04-921,Anti-GluR6/7 Antibody, clone NL9, rabbit monoclonal

    产品名称：Anti-GluR6/7 Antibody, clone NL9, rabbit monoclonal
    产品型号：04-921
    Anti-GluR6/7 Antibody, clone NL9 is an antibody against GluR6/7 for use in IP & WB.

    merck millipore,默克密理博,04-921,Anti-GluR6/7 Antibody, clone NL9, rabbit monoclonal

  • 产品介绍
  • merck millipore,默克密理博,04-921,Anti-GluR6/7 Antibody, clone NL9, rabbit monoclonal

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBRbCulture SupernatantMonoclonal Antibody
    描述
    产品目录编号 04-921
    Replaces 05-921
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-GluR6/7 Antibody, clone NL9, rabbit monoclonal
    产品信息
    格式 Culture Supernatant
    控制
    • Mouse brain tissue, rat brain microsomal preparation, human brain lysates
    应用
    应用 Anti-GluR6/7 Antibody, clone NL9 is an antibody against GluR6/7 for use in IP & WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated, synthetic peptide corresponding to amino acids 894-908 (C-terminus) of rat GluR6. The immunizing sequence is identical in human.
    克隆 NL904
    宿主 Rabbit
    特异性 Recognizes GluR6/7.
    同种型 IgG
    品种反应性 RatHumanMouse
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_021956
    Entrez基因汇总 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation.
    基因符号
    • GluR6
    • GRIK2
    • GLR6
    • EAA4
    • GluR-6
    • GLUR6
    • MGC74427
    纯化方法 None
    UniProt编号
    • Q13002
    UniProt汇总 FUNCTION: SwissProt: Q13002 # Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
    SIZE: 908 amino acids; 102583 Da
    SUBUNIT: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers (Probable). Assembles into a kainate-gated homomeric channel that does not bind AMPA. GRIK2 associated to GRIK5 forms functional channels that can be gated by AMPA (By similarity). Interacts with DLG4.
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
    TISSUE SPECIFICITY: Expression is higher in cerebellum than in cerebral cortex.
    SIMILARITY: SwissProt: Q13002 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
    MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate > quisqualate > 6- cyano-7-nitroquinoxaline-2,3-dione > L-glutamate = 6,7- dinitroquinoxaline-2,3-dione > dihydrokainate.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot analysis.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,04-921,Anti-GluR6/7 Antibody, clone NL9, rabbit monoclonal

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