merck millipore,默克密理愽
  • merck millipore,默克密理博,04-578,Anti-Smac/DIABLO Antibody, rabbit monoclonal, clone Y12

  • merck millipore,默克密理博,04-578,Anti-Smac/DIABLO Antibody, rabbit monoclonal, clone Y12

    产品名称：Anti-Smac/DIABLO Antibody, rabbit monoclonal, clone Y12
    产品型号：04-578
    Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-Smac/DIABLO Antibody, Rabbit, clone Y12 detects More>>

    merck millipore,默克密理博,04-578,Anti-Smac/DIABLO Antibody, rabbit monoclonal, clone Y12

  • 产品介绍
  • merck millipore,默克密理博,04-578,Anti-Smac/DIABLO Antibody, rabbit monoclonal, clone Y12

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HICC, FC, WBRbPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-578
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Smac/DIABLO Antibody, rabbit monoclonal, clone Y12
    Alternate Names
    • Second Mitochondria-derived Activator of Caspases/Direct IAP Binding Protein with Low PI
    背景信息 Smac/DIABLO (Second Mitochondria-derived Activator of Caspases/Direct IAP Binding Protein with Low PI) is localized to the mitochondria and involved in activating programmed cell death, or apoptosis (1). In response to apoptotic stimuli, Smac/DIABLO is released from the mitochondria and binds anti-apoptotic IAP proteins, supressing their inhibitory activity and promoting caspase activation (1,2). This interaction involves primarily the amino-terminal residues of Smac/DIABLO with the BIR3 region of the IAP protein (3,4).
    产品信息
    格式 Purified
    演示 Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
    应用
    应用 Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-Smac/DIABLO Antibody, Rabbit, clone Y12 detects level of Smac/DIABLO & has been published & validated for use in FC, IP, WB, IC, IH(P).
    主要应用
    • Immunocytochemistry
    • Flow Cytometry
    • Western Blotting
    应用说明 WB: 1:1,000
    IHC: 1:10 (Paraffin-embedded human skin cancer tissue)
    ICC: 1:10
    Flow Cytometry: 1:10-50
    IP: 1:10-80
    生物信息
    免疫原品种 A synthetic peptide corresponding to C-terminal residues human Smac/DIABLO.
    克隆 Y12
    宿主 Rabbit
    特异性 Recognizes Human, Rat Smac/Diablo.
    品种反应性 RatHuman
    Species Reactivity Note Human, Rat (positive control: Jurkat cell lysate)
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_138930.2
    • NM_019887.3
    • NM_138929.2
    Entrez基因汇总 This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Several alternatively spliced transcript variants that encode distinct isoforms have been described for this gene but the validity of some transcripts, and their predicted ORFs, has not been determined conclusively.
    基因符号
    • SMAC3
    • DIABLO
    • SMAC
    • DIABLO-S
    • FLJ25049
    • 0610041G12Rik
    • diablo
    • FLJ10537
    UniProt编号
    • Q9NR28
    UniProt汇总 FUNCTION: SwissProt: Q9NR28 # Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP).
    SIZE: 239 amino acids; 27131 Da
    SUBUNIT: Interacts with NGFRAP1/BEX3 (By similarity). Homodimer. Interacts with BIRC2, BIRC3, BIRC4/XIAP and BIRC7.
    SUBCELLULAR LOCATION: Mitochondrion. Note=But released into the cytosol when cells undergo apoptosis.
    TISSUE SPECIFICITY: Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes.
    DOMAIN:SwissProt: Q9NR28 The mature N-terminus mediates interaction with BIRC4/XIAP.
    SIMILARITY:
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store at -20 °C. Stable for 12 months from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,04-578,Anti-Smac/DIABLO Antibody, rabbit monoclonal, clone Y12

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