merck millipore,默克密理博,04-463,Anti-IL-15 Antibody, rabbit monoclonal

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merck millipore,默克密理博,04-463,Anti-IL-15 Antibody, rabbit monoclonal
产品名称：Anti-IL-15 Antibody, rabbit monoclonal
产品型号：04-463
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-IL-15 Antibody, rabbit is validated for us More>>

merck millipore,默克密理博,04-463,Anti-IL-15 Antibody, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-463,Anti-IL-15 Antibody, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	WB	Rb	Purified	Monoclonal Antibody

描述
产品目录编号	04-463
品牌系列	Upstate
商名	Upstate
描述	Anti-IL-15 Antibody, rabbit monoclonal

产品信息
格式	Purified
演示	100 μL of rabbit monoclonal IgG in 60% storage buffer (50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-IL-15 Antibody, rabbit is validated for use in WB for the detection of IL-15.
主要应用	Western Blotting

生物信息
免疫原品种	KLH-conjugated recombinant human IL-15.
宿主	Rabbit
特异性	Recognizes recombinant human IL-15.
同种型	IgG
品种反应性	Human
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_172174.1 NM_000585.2
Entrez基因汇总	The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.
基因符号	IL-15 IL15 MGC9721
UniProt编号	P40933
UniProt汇总	FUNCTION: SwissProt: P40933 # Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha. SIZE: 162 amino acids; 18086 Da SUBCELLULAR LOCATION: Isoform IL15-S48AA: Secreted. & Isoform IL15-S21AA: Cytoplasm. Nucleus. Note=IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components. TISSUE SPECIFICITY: Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15- S21AA is preferentially expressed in tissues such as testis and thymus. SIMILARITY: SwissProt: P40933 ## Belongs to the IL-15 family.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

储存和货运信息

存储条件

2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.