merck millipore,默克密理愽
  • merck millipore,默克密理博,04-281,Anti-phospho-EGFR (Thr669) Antibody, clone 5F10

  • merck millipore,默克密理博,04-281,Anti-phospho-EGFR (Thr669) Antibody, clone 5F10

    产品名称：Anti-phospho-EGFR (Thr669) Antibody, clone 5F10
    产品型号：04-281
    Anti-phospho-EGFR (Thr669) Antibody, clone 5F10 detects level of phospho-EGFR (Thr669) & has been published & validated for use in WB.

    merck millipore,默克密理博,04-281,Anti-phospho-EGFR (Thr669) Antibody, clone 5F10

  • 产品介绍
  • merck millipore,默克密理博,04-281,Anti-phospho-EGFR (Thr669) Antibody, clone 5F10

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-281
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-EGFR (Thr669) Antibody, clone 5F10
    Alternate Names
    • ERBB, ERBB1, epidermal growth factor receptor
    • ERBB
    • ERBB1
    产品信息
    格式 Purified
    控制
    • Includes PMA and pervanadate treated A431 cell lysate as a positive control
    演示 100 µg of mouse monoclonal IgG1 liquid in 0.01 mg/ml PBS containing 0.09% sodium azide, PEG, and sucrose with 50 % glycerol.
    应用
    应用 Anti-phospho-EGFR (Thr669) Antibody, clone 5F10 detects level of phospho-EGFR (Thr669) & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated synthetic peptide encompassing the surrounding amino acids of Thr 669 in human EGFR.
    克隆 5F10
    宿主 Mouse
    特异性 Recognizes EGFR when phosphorylated at Threonine 669.
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_201284.1
    • NM_005228.3
    • NM_201282.1
    • NM_201283.1
    基因符号
    • mENA
    • EGFR
    • ERBB1
    • ERBB
    修改
    • Phosphorylation
    纯化方法 Thiophilic adsoption and size exclusion chromatography
    UniProt编号
    • P00533
    UniProt汇总 FUNCTION: SwissProt: P00533 # Isoform 2/truncated isoform may act as an antagonist.
    SIZE: 1210 amino acids; 134277 Da
    SUBUNIT: Binds RIPK1. CBL interacts with the autophosphorylated C- terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1.
    SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
    TISSUE SPECIFICITY: Expressed in placenta. Isoform 2 is also expressed in ovarian cancers.
    PTM: Phosphorylation of Ser-695 is partial and occurs only if Thr- 693 is phosphorylated. & Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.DISEASE:SwissProt: P00533 # Defects in EGFR are associated with lung cancer [MIM:211980].
    SIMILARITY: SwissProt: P00533 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.
    MISCELLANEOUS: Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -20°C from date of shipment
    包装信息
    数量 100 µg

    merck millipore,默克密理博,04-281,Anti-phospho-EGFR (Thr669) Antibody, clone 5F10

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