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品种反应性 主要应用 宿主 格式 抗体类型 H, R, M WB M Ascites Monoclonal Antibody 描述 产品目录编号 04-1573 描述 Anti-Ataxin-7 Antibody, clone 3SCA-1C1 Alternate Names - ADCAII, OPCA3, SCA7
背景信息 Ataxin-7 is a protein of unknown function. However, since this protein contains a nuclear localization sequence and is found to be localized in the nucleus, it has been postulated to be a potential transcription factor. Spinocerebellar ataxia-7 (one of a group of hereditary neurodegenrative diseases) is caused by an expanded CAG repeat in the gene encoding ataxin-7 (the diseased allele associated with Spinocerebellar ataxia-7, contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele). In cells where there is a mutation of the SCA7 gene, ataxin-7 accumulates in intranuclear inclusions and can result in cell death. Spinocerebellar ataxia (SCA) is one of a group of genetic disorders characterized by slowly progressive incoordination of gait and often associated with poor coordination of hands, speech, and eye movements. Frequently, atrophy of the cerebellum occurs. 产品信息 格式 Ascites 控制 - Rat brain tissue lysate.
演示 Unpurified mouse IgG1, k antibody in ascites fluid without preservatives. 应用 应用 Anti-Ataxin-7 Antibody, clone 3SCA-1C1 is an antibody against Ataxin-7 for use in WB. 主要应用 - Western Blotting
应用说明 ELISA: A 1:500-1:5,000 dilution of a previous lot of 04-1573 was used in ELISA, as reported by an outside laboratory. Immunocytochemistry: A 1:500-1:5,000 dilution of a previous lot of 04-1573 was used in IC, as reported by an outside laboratory. 生物信息 免疫原品种 Recombinant human Ataxin 7 as a fusion protein (aa 1 to aa 229). 表位 Epitope mapped between aa 66 and aa 119. 克隆 clone 3SCA-1C1 宿主 Mouse 特异性 This antibody recognizes Ataxin-7 protein. 同种型 IgG1κ 品种反应性 HumanRatMouse Species Reactivity Note Demonstrated to react with Rat and Mouse. Predicted to react with Human based on immunogen design. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_000324
Entrez基因汇总 The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with Spinocerebellar ataxia-7, contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele. The exact function of this gene is not known, however, since the encoded protein contains a nuclear localization sequence, and is found to be localized in the nucleus, it has been postulated to be a potential transcription factor. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. 基因符号 - ATXN7
纯化方法 Unpurified UniProt编号 - O15265
UniProt汇总 UniProtKB/Swiss-Prot: ATX7_HUMAN, O15265 (See protein sequence)
Recommended Name: Ataxin-7
Size: 892 amino acids; 95451 Da
Subunit: Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H,
GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP, TAF9 and ATXN7. The STAGA core
complex is associated with a subcomplex required for histone deubiquitinylation composed of
ATXN7L3, ENY2 and USP22. Interacts with SORBS1, PSMC1 and CRX. Interacts with TRRAP, GCN5L2 and
TAF10
Subcellular location: Nucleus. Nucleus, nucleolus. Nucleus matrix. Note=In addition to a diffuse
distribution throughout the nucleus, it is associated with the nuclear matrix and the nucleolus
Subcellular location: Isoform b: Cytoplasm
Secondary accessions: O75328 O75329 Q9Y6P8
Alternative splicing: 2 isoforms: O15265-1 O15265-2产品使用声明 质量保证 Evaluated by Western Blotting of Rat brain lysate. Western Blotting: Representative lot data: A 1:1000 dilution of this antibody detected Ataxin-7 in 10ug of Rat brain tissue lysate. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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