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品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 04-135 品牌系列 Upstate
商名 - Upstate
描述 Anti-Brachyury Antibody, clone 3E4.2 Alternate Names - transcription factor T
- T brachyury (mouse) homolog
- T brachyury-like
- T protein
- T, brachyury homolog (mouse)
- T brachyury (mouse) homolog
背景信息 The Brachyury protein is a T-box transcription factor that is one of the earliest indicators of mesoderm formation during embryonic development. As the brachyury protein family is essential for the formation of the posterior body in all vertebrates, Brachyury has been shown to be expressed during gastrula and neurula stages, as well as in the developing notochord. Consequently, when mutations occur within the brachyury gene, severe vertebral malformations have been found to occur, as a direct result. In addition, current findings also indicate that the dysregulation of brachyury may also be linked to the formation of chordomas, which are malignant tumors that develop along the spine. 产品信息 格式 Purified 演示 Purified mouse monoclonal IgG1κ in buffer containing PBS with 0.05% sodium azide. 应用 应用 This Anti-Brachyury Antibody, clone 3E4.2 is validated for use in WB for the detection of Brachyury. 主要应用 - Western Blotting
生物信息 免疫原品种 Synthetic human brachyury peptide, a.a. 224-435. 表位 C-terminus 克隆 3E4.2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This monoclonal antibody recognizes the brachyury protein. 同种型 IgG1κ 品种反应性 Human Species Reactivity Note Reacts with human. Reactivity with other species has not been tested. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_003172
Entrez基因汇总 The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. 基因符号 - TFT
- MGC104817
- OTTHUMP00000017588
- TF
纯化方法 Protein G purfied UniProt编号 - O15178
UniProt汇总 FUNCTION: SwissProt: O15178 # Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.
SIZE: 435 amino acids; 47443 Da
SUBUNIT: Monomer (By similarity).
Nucleus.
DISEASE: SwissProt: O15178 # Genetic variations in T are associated with susceptibility to neural tube defects (NTD) [MIM:182940]. NTD are common congenital malformations. Spina bifida, which results from malformations in the caudal region of the neural tube, is compatible with life but associated with significant morbidity, including lower limb paralysis.
SIMILARITY: SwissProt: O15178 ## Contains 1 T-box DNA-binding domain.产品使用声明 质量保证 Routinely evaluated by Western blot on NT2 cell lysates.
Western Blotting:
Recommended working dilutions are 1:1000.
使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. Avoid repeat freeze/thaw cycles. 包装信息 数量 100 µg
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