merck millipore,默克密理博,04-1123,Anti-CD44 [H-CAM] Antibody, clone EPR1013Y, rabbit monoclonal

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merck millipore,默克密理博,04-1123,Anti-CD44 [H-CAM] Antibody, clone EPR1013Y, rabbit monoclonal
产品名称：Anti-CD44 [H-CAM] Antibody, clone EPR1013Y, rabbit monoclonal
产品型号：04-1123
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-CD44 [H-CAM] Antibody, clone EPR1013Y, Rabbit d More>>

merck millipore,默克密理博,04-1123,Anti-CD44 [H-CAM] Antibody, clone EPR1013Y, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-1123,Anti-CD44 [H-CAM] Antibody, clone EPR1013Y, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	FC, WB, ICC	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	04-1123
描述	Anti-CD44 [H-CAM] Antibody, clone EPR1013Y, rabbit monoclonal
Alternate Names	homing function and Indian blood group system CD44 antigen CD44 antigen (homing function and Indian blood groupsystem) CD44 molecule (Indian blood group) CDW44 antigen Extracellular matrix receptor III GP90 lymphocyte homing/adhesion receptor Heparan sulfate proteoglycan Hermes antigen Hyaluronate receptor Phagocytic glycoprotein I antigen gp90 homing receptor cell adhesion molecule cell surface glycoprotein CD44 chondroitin sulfate proteoglycan 8 extracellular matrix receptor-III hematopoietic cell E- and L-selectin ligand
背景信息	Recent studies indicate that the expression of CD44 (H-CAM) on the cell surface changes profoundly during tumor metastasis, particularly during the progression of various carcinomas. Sequencing analysis reveals that CD44 exists in different forms (at least 15 isoforms have been identified) that are variants of the common or standard hemopoietic form CD44s. Specifically, the human CD44 gene contains 19 exons, out of which 10 exons can potentially be alternatively spliced. In particular, CD44s contains exons 1-15 and exons 15-19. The other exons (e.g. 6-14) are also spliced in a variety of different cells. It has been suggested that expression of CD44 variants with the additional exon 14 (so-called v10) is responsible for tumor progression and metastasis. In fact, CD44v10 expression has been used as an indicator of metastasis.

产品信息
格式	Unpurified
控制	TF-1 cell lysate.
演示	Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-CD44 [H-CAM] Antibody, clone EPR1013Y, Rabbit detects level of CD44 [H-CAM] & has been published & validated for use in IH(P), WB, IC, FC.
主要应用	Flow Cytometry Western Blotting Immunocytochemistry
应用说明	Immunohistochemistry Analysis: 1:100 - 250 dilution from a previous lot detected CD44 in human urinary bladder tissue. Immunocytochemistry: 1:100-250 dilution from a previous lot of this antibody was used in IC. Flow Cytometry: 1:30 dilution from a previous lot of this antibody was used in FC.

生物信息
免疫原品种	Synthetic peptide corresponding to residues in human CD44.
克隆	EPR1013Y
宿主	Rabbit
特异性	This antibody recognizes CD44.
同种型	IgG
品种反应性	Human
Species Reactivity Note	Human
抗体类型	Monoclonal Antibody
Entrez基因编号	P16070
基因符号	Pgp1 CD44R CDW44 CDw44 CSPG8 ECMR-III Epican HCELL HUTCH-I IN LHR MC56 MDU2 MDU3 MGC10468 MIC4 MUTCH-I PGP-1 PGP-I
纯化方法	Unpurified
UniProt编号	P16070
UniProt汇总	FUNCTION: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. SUBUNIT STRUCTURE: Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: An epithelial CD44E) is expressed by cells of epithelium and highly expressed by carcinomas. An hematopoietic CD44H) is expressed by cells of mesodermal origin. Expression is repressed in neuroblastoma cells. PTM: Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors. N-glycosylated. O-glycosylated; contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672. POLYMORPHISM: CD44 is responsible for the Indian blood group system. The molecular basis of the In(A)=In1/In(B)=In2 blood group antigens is a single variation in position 46; In(B), the most frequent allele, has Arg-46. SEQUENCE SIMILARITIES: Contains 1 Link domain.

产品使用声明
质量保证	Evaluated by Western Blot on TF-1 cell lysate. Western Blot Analysis: 1:5,000 dilution of this antibody was used to detect CD44 in TF-1 cell lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20ºC from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

包装信息
数量	100 µL

merck millipore,默克密理博,04-1123,Anti-CD44 [H-CAM] Antibody, clone EPR1013Y, rabbit monoclonal

上一件merck millipore产品：merck millipore,默克密理博,ABN165,Anti-MMEL1 Antibody
下一件merck millipore产品：merck millipore,默克密理博,AB15810,Anti-Substance P Receptor Antibody

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