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品种反应性 主要应用 宿主 格式 抗体类型 M, B, H WB, ELISA, FC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB9714 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-RAGE Antibody Alternate Names - Receptor for Advanced Glycosylation End Products
背景信息 RAGE is a member of the immunoglobulin superfamily of cell surface molecules that binds molecules that have been irreversibly modified by non-enzymatic glycation and oxidation, and are know as advanced glycation end products (AGEs). It is expressed by endothelium, mononuclear phagocytes, neurons and smooth muscle cells. Whereas RAGE is present at high levels during development, especially in the central nervous system, its levels decline during maturity.The increased expression of RAGE is associated with several pathological states, such as diabetic vasculopathy, neuropathy, retinopathy and other disorders, including Alzheimer's disease and immune/inflammatory reactions of the vessel walls. In diabetic tissues, the production of RAGE is due to the overproduction of AGEs that eventually overwhelm the protective properties of RAGE. This results in oxidative stress and endothelial cell dysfunction that leads to vascular disease in diabetics. In the brain, RAGE also binds amyloid beta (Ab). Because Ab is overproduced in neurons and vessels in the brains of Alzheimer disease, this leads to the hyperstimulation of RAGE. The RAGE-Ab interaction is thought to result in oxidative stress leading to neuronal degeneration. 产品信息 格式 Affinity Purified 演示 Liquid in PBS with 0.1% sodium azide. 应用 应用 This Anti-RAGE Antibody is validated for use in ELISA, FC, WB for the detection of RAGE. 主要应用 - Western Blotting
- ELISA
- Flow Cytometry
应用说明 Western blot: 1:1,000-1:2,500 on extracts from bovine and mouse lungs and in HeLa cells expressing human soluble RAGE.
Flow cytometry: 1 μg/mL per million cells using a PE conjugated second antibody.
ELISA: 1:10,000-1:50,000 against the immunogen peptide.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide from human RAGE, amino acids 39-58 (KGAPKKPPQRLEWKLNTGRT). 宿主 Rabbit 特异性 RAGE (Receptor for Advanced Glycosylation End Products). 同种型 IgG 品种反应性 MouseBovineHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_172197.1
- NM_001136.3
Entrez基因汇总 This gene encodes a member of the immunoglobulin superfamily of cell surface molecules. It is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products. The gene lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Alternative splicing results in two transcript variants encoding different isoforms. 基因符号 - MGC22357
- AGER
- RAGE
纯化方法 Immunoaffinity purified UniProt编号 - Q15109
UniProt汇总 FUNCTION: SwissProt: Q15109 # Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Receptor for amyloid beta peptide.
SIZE: 404 amino acids; 42803 Da
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
TISSUE SPECIFICITY: Endothelial cells.
SIMILARITY: SwissProt: Q15109 ## Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 Ig-like V-type (immunoglobulin-like) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,AB15810,Anti-Substance P Receptor Antibody
下一件merck millipore产品：merck millipore,默克密理博,4750-OP,OmniPur Glycerol - CAS 56-81-5 - Calbiochem
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