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merck millipore,默克密理博,RLI1MAG-92K,MILLIPLEX MAP Rat Liver Injury Panel - Toxicity Multiplex Assay
产品名称：MILLIPLEX MAP Rat Liver Injury Panel - Toxicity Multiplex Assay
产品型号：RLI1MAG-92K
The analytes available for this multiplex kit are: Liver-type arginase 1 (ARG1), aspartate transaminase 1 (GOT1), α-glutathianone S-transferase (GSTα), sorbitol dehydrogenase (SDH), and 5'-Nucleotidas More>>
merck millipore,默克密理博,RLI1MAG-92K,MILLIPLEX MAP Rat Liver Injury Panel - Toxicity Multiplex Assay
- 产品介绍
重要规格表
可用的分析物 品种反应性 主要应用 检测方法 5'-NT/CD73, ARG1, GOT1, GSTα, SDH R Mplex Luminex xMAP 描述 产品目录编号 RLI1MAG-92K 商名 - MILLIPLEX
描述 MILLIPLEX MAP Rat Liver Injury Panel - Toxicity Multiplex Assay 概述 The MILLIPLEX® MAP Rat Liver Injury Magnetic Bead Panel (RLI1MAG-92K) contains all the components necessary to simultaneous quantify the following 5 analytes in serum and plasma samples:
• Liver-Type Arginase 1 (ARG1)*
• Aspartate transaminase 1 (GOT1)
• α-glutathione S-transferase (GSTα)*
• Sorbitol Dehydrogenase (SDH)*
• 5'-Nucleotidase/CD73 (5’-NT)
*ARG1, GSTα, and SDH are biomarkers listed in the Predictive Safety Testing Consortium (PSTC) project pipeline which have a strong translational role in drug safety testing.
EMD Millipore provides a valuable research assay to investigate multiple biomarkers of liver injury in rat serum and plasma samples using the Luminex xMAP® instrument platform. This kit uses a 96-well format, contains a lyophilized standard cocktail, two quality controls and can measure up to 38 serum or plasma samples in duplicate.背景信息 Drug toxicity is the leading cause of acute liver failure in the United States. Patients with liver damage generally display elevated amounts of specific liver proteins in serum; these proteins can serve as biomarkers of drug-related liver toxicity. Monitoring these biomarkers can greatly help clinicians avoid drug-induced liver failure. Performing laboratory tests to characterize the side effects of potential therapeutics is an essential part of drug development. The rat is a leading animal model for these pre-clinical toxicity studies.
The search for sensitive, organ-specific toxicity biomarkers is complemented by the development of novel assays to measure these critical analytes. Liver-Type Arginase 1 (ARG1), α-glutathione S-transferase (GSTα), and Sorbitol Dehydrogenase (SDH) are biomarkers listed in the Predictive Safety Testing Consortium (PSTC) project pipeline which have a strong translational role in drug safety testing. Aspartate transaminase 1 (GOT1) and 5'-Nucleotidase / CD73 (5’-NT) are traditional biomarkers recognized by both the Food and Drug Administration (FDA) and its European counterpart, the European Medicines Agency (EMA).产品信息 部件 - 2 Foil Plate Sealers
- Rat Liver Injury Standard, 1 vial, lyophilized
- Rat Liver Injury Quality Control 1, 1 vial, lyophilized
- Rat Liver Injury Quality Control 2, 1 vial, lyophilized
- Assay Buffer, 1 bottle, 30 mL
- Wash Buffer, 10X (0.05% Proclin), 2 bottles, 30 mL ea
- Rat Liver Injury Detection Antibodies, 1 bottle, 3.2 mL
- Streptavidin-Phycoerythrin, 1 bottle, 3.2 mL
- Mixing Bottle, 1 bottle
- Sample Plate, 96 well format, 1 plate
检测方法 Luminex xMAP 配置 Design your multiplex kit by choosing analytes. 精度（%） - Intra-assay: <10
- Inter-assay: <15
板面类型 MAGNETIC Toxicity 应用 应用 The analytes available for this multiplex kit are: Liver-type arginase 1 (ARG1), aspartate transaminase 1 (GOT1), α-glutathianone S-transferase (GSTα), sorbitol dehydrogenase (SDH), and 5'-Nucleotidase (5'-NT/CD73). 主要应用 - Multiplexing
应用说明 • This is an overnight assay.
• This assay requires 25 µL of 1:25 diluted serum or plasma sample per well in kit Assay Buffer (please dilute per protocol instructions).生物信息 特异性 There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes within a panel. 品种反应性 Rat 可用的分析物 - 5'-NT/CD73
- ARG1
- GOT1
- GSTα
- SDH
化验面板 Everything you need in a single kit. 交叉反应性 There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes within a panel. 准确度 - 77% - 92%
理化信息 灵敏度 - Please see kit protocol for individual assay sensitivities.
- 0.021 - 4.038 ng/mL (MinDC+2SD).
稀释的线性 Contact technical support for this information. 标准曲线范围 - 5'-NT/CD73: 0.04 – 30.0 ng/mL
- ARG1: 0.10 – 75.0 ng/mL
- GOT1: 0.08 – 60.0 ng/mL
- GSTα: 0.02 – 15.0 ng/mL
- SDH: 0.62 – 450.0 ng/mL
产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Recommended storage for kit components is 2 - 8°C. 包装信息 数量 96-well plate
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