merck millipore,默克密理愽
  • merck millipore,默克密理博,444155,MDMX Antagonist, SJ-172550 - CAS 431979-47-4 - Calbiochem

  • merck millipore,默克密理博,444155,MDMX Antagonist, SJ-172550 - CAS 431979-47-4 - Calbiochem

    产品名称：MDMX Antagonist, SJ-172550 - CAS 431979-47-4 - Calbiochem
    产品型号：444155
    The MDMX Antagonist, SJ-172550, also referenced under CAS 431979-47-4, controls the biological activity of MDMX.

    merck millipore,默克密理博,444155,MDMX Antagonist, SJ-172550 - CAS 431979-47-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,444155,MDMX Antagonist, SJ-172550 - CAS 431979-47-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₂H₂₁ClN₂O₅431979-47-4
    描述
    概述 A cell-permeable phenyl-pyrazolylidene compound that competes with p53-derived peptide (aa 15-29) binding to MDMX in cell-free binding assays (EC50 = 2.3 µM) in a reversible manner and effectively disrupts cellular p53-MDMX interaction (IC50 <20 µM in C33A, HER, and Weri1 cultures), while exhibiting much weaker affinity toward MDM2 (EC50 = 26 µM in p53 peptide competition assays). MDMX inhibition by 20 µM SJ-172550 and MDM2 inhibition by 5 µM Nutlin-3a (Cat. Nos. 444143 & 444151) are both shown to result in reduced proliferation and increased cellular caspase-3 in cultured cells, however, only MDM2, but not MDMX, inhibition results in a significant p53 protein level upregulation.
    产品目录编号 444155
    品牌系列 Calbiochem®
    同义词 Methyl-2-(2-chloro-6-ethoxy-4-(E)-(3-methyl-5-oxo-1-phenyl-pyrazol-4-ylidene)methyl)phenoxy)acetate, MDMX Inhibitor II
    参考
    参考 Reed, D., et al. 2010. J. Biol. Chem. 285, 10786.
    产品信息
    CAS号 431979-47-4
    形式 Orange solid
    Hill配方 C₂₂H₂₁ClN₂O₅
    化学配方 C₂₂H₂₁ClN₂O₅
    Molar Mass 428.9
    结构配方图像
    生物信息
    纯度 ≥95% by NMR
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,444155,MDMX Antagonist, SJ-172550 - CAS 431979-47-4 - Calbiochem

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