- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,MABT42,Anti-Integrin beta-2 (CD18) Antibody, clone M18/2
产品名称：Anti-Integrin beta-2 (CD18) Antibody, clone M18/2
产品型号：MABT42
This Anti-Integrin beta-2 (CD18) Antibody, clone M18/2 is validated for use in FC, IP for the detection of Integrin beta-2 (CD18).
merck millipore,默克密理博,MABT42,Anti-Integrin beta-2 (CD18) Antibody, clone M18/2
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M FC R Purified Monoclonal Antibody 描述 产品目录编号 MABT42 描述 Anti-Integrin beta-2 (CD18) Antibody, clone M18/2 Alternate Names - cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor)
- integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
- integrin beta chain, beta 2
- complement receptor C3 beta-subunit
- leukocyte cell adhesion molecule CD18
- integrin beta-2
- Complement receptor C3 subunit beta
- Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
- leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
- CD18 antigen
- integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1
- macrophage antigen 1 (mac-1) beta subunit)
- cell surface adhesion glycoprotein (LFA-1,CR3,P150,959 beta subunit precursor)
背景信息 Integrin beta-2, also known as CD18, is an adhesion receptor in neutrophils that interacts with cytohesin-1 intracellularly. Integrin beta is instrumental in activation-dependent adhesion and adhesion-dependent signaling. Expression of integrin beta-2 has a positive correlation with patient survival from malignant B cell lymphoma. 产品信息 格式 Purified 控制 - Mouse EL4 cells
演示 Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-Integrin beta-2 (CD18) Antibody, clone M18/2 is validated for use in FC, IP for the detection of Integrin beta-2 (CD18). 主要应用 - Flow Cytometry
应用说明 Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP (Sanchez-Madrid, F., et al. (1983). J. ExP. MED. 158:586-602).
Inhibition Analysis: A previous lot of this antibody was shown to inhibit lymphoma metastasis (Zahalka, M. A. et al. (1993) J. Immunol. 150, 4466).生物信息 免疫原品种 Whole B10 mouse spleen cells enriched with T-cells. 克隆 clone M18/2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rat 同种型 IgG2aκ 品种反应性 Mouse Species Reactivity Note Demonstrated to react with mouse. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_032430
基因符号 - LAD2
- CD18
- LFA-1
- MAC-1
- MF17
- MFI7
- LCAMB
纯化方法 Protein G Purified UniProt编号 - P11835
UniProt汇总 FUNCTION: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.
SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with COPS5 and RANBP9 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SEQUENCE SIMILARITIES: Belongs to the integrin beta chain family.
Contains 1 VWFA domain.产品使用声明 质量保证 Evaluated by Flow Cytometry in mouse EL4 cells.
Flow Cytometry Analysis: 10 µg of this antibody detected Integrin beta-2 in mouse EL4 cells.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,539305,Protein G, Alkaline Phosphatase Conjugate
下一件merck millipore产品：merck millipore,默克密理博,341608,FGF Receptor Tyrosine Kinase Inhibitor - CAS 192705-79-6 - Calbiochem
相关产品
merck millipore,默克密理博,525282,PhosphoDetect™ Phosphoserine Detection Kit
merck millipore,默克密理博,A-004-C,Poly-L-Ornithine Solution (0.01%)
merck millipore,默克密理博,539165,Proteasome Inhibitor Set II - Calbiochem
merck millipore,默克密理博,4255-OP,OmniPur Horse Radish Peroxidase
merck millipore,默克密理博,539305,Protein G, Alkaline Phosphatase Conjugate
merck millipore,默克密理博,341608,FGF Receptor Tyrosine Kinase Inhibitor - CAS 192705-79-6 - Calbiochem
merck millipore,默克密理博,434692,Leukotriene C₄ - CAS 72025-60-6 - Calbiochem
merck millipore,默克密理博,ABN297,Anti-Oxytocin receptor Antibody
