merck millipore,默克密理博,MABS788,Anti-phospho-IkappaB-alpha (Ser36), clone EPR6235(2), Rabbit Monoclonal Antibody

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merck millipore,默克密理博,MABS788,Anti-phospho-IkappaB-alpha (Ser36), clone EPR6235(2), Rabbit Monoclonal Antibody
产品名称：Anti-phospho-IkappaB-alpha (Ser36), clone EPR6235(2), Rabbit Monoclonal Antibody
产品型号：MABS788
Anti-phospho-IkappaB-alpha (Ser36), clone EPR6235(2), Rabbit Monoclonal is an antibody against phospho-IkappaB-alpha (Ser36) for use in Western Blotting.

merck millipore,默克密理博,MABS788,Anti-phospho-IkappaB-alpha (Ser36), clone EPR6235(2), Rabbit Monoclonal Antibody

产品介绍

merck millipore,默克密理博,MABS788,Anti-phospho-IkappaB-alpha (Ser36), clone EPR6235(2), Rabbit Monoclonal Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	MABS788
描述	Anti-phospho-IkappaB-alpha (Ser36), clone EPR6235(2), Rabbit Monoclonal Antibody
Alternate Names	NFKBI NF-kappa-B inhibitor alpha I-kappa-B-alpha IkB-alpha IkappaBalpha Major histocompatibility complex enhancer-binding protein MAD3 NFKBIA IKBA MAD3
背景信息	NF-kappa-B inhibitor alpha, also known as I-kappa-B-alpha or IkB-alpha or IkappaBalpha or Major histocompatibility complex enhancer-binding protein MAD3, and encoded by the gene name NFKBIA or IKBA or MAD3 or NFKBI, is present in the cytosol in an inactive state, complexed with the inhibitory IkappaB-alpha protein. In response to many different NF-kappaB-inducing agents including T-cell mitogens, proinflammatory cytokines, and viral transactivators the inhibitory IkappaB-alpha is rapidly phosphorylated and degraded. Phosphorylation of IkappaB-alpha at Ser32 and Ser36 has been shown to stimulate conjugation with ubiquitin and subsequent degradation of IkappaB-alpha. Activation of NF-kappaB can also be achieved after tyrosine phosphorylation of IkappaBalpha at tyrosine 42, an event that also ultimately leads to the dissociation of NF-kappaB and IkappaBalpha. Phosphorylation of IkappaB-alpha at Ser32 and Tyr42 is critical for activation of NF-kappaB, which then translocates to the nucleus and induces transcription of genes that protect organism.

产品信息
格式	Unpurified
演示	Rabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.

应用
应用	Anti-phospho-IkappaB-alpha (Ser36), clone EPR6235(2), Rabbit Monoclonal is an antibody against phospho-IkappaB-alpha (Ser36) for use in Western Blotting.
主要应用	Western Blotting
应用说明	Produced in collaboration with Epitomics™

生物信息
免疫原品种	Synthetic peptide corresponding to human phospho-IkappaB-alpha (Ser36).
克隆	EPR6235(2)
浓缩	Please refer to lot specific datasheet.
宿主	Rabbit
同种型	IgG
品种反应性	Human
Species Reactivity Note	Human
抗体类型	Monoclonal Antibody
基因符号	NFKBI NFKBIA IKBA MAD3
纯化方法	Unpurified
UniProt编号	P25963

产品使用声明
质量保证	Evaluated by Western Blotting in HeLa cell lysate and HeLa cell lysate treated with FBS and Calyculin A. Western Blotting Analysis: A 1:10,000-50,000 dilution of this antibody detected phospho-IkappaB-alpha (Ser36) in HeLa cell lysate and HeLa cell lysate treated with FBS and Calyculin A.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.