merck millipore,默克密理愽
  • merck millipore,默克密理博,MABS50,Anti-Cdk5 Antibody, clone 1H3

  • merck millipore,默克密理博,MABS50,Anti-Cdk5 Antibody, clone 1H3

    产品名称：Anti-Cdk5 Antibody, clone 1H3
    产品型号：MABS50
    Anti-Cdk5 Antibody, clone 1H3 detects level of Cdk5 & has been published & validated for use in WB, IC, IH.

    merck millipore,默克密理博,MABS50,Anti-Cdk5 Antibody, clone 1H3

  • 产品介绍
  • merck millipore,默克密理博,MABS50,Anti-Cdk5 Antibody, clone 1H3

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MIHC, WB, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABS50
    描述 Anti-Cdk5 Antibody, clone 1H3
    Alternate Names
    • TPKII catalytic subunit
    • cyclin-dependent kinase 5
    • Tau protein kinase II catalytic subunit
    • Serine/threonine-protein kinase PSSALRE
    • protein kinase CDK5 splicing
    背景信息 Cyclin-dependent kinase 5 (CDK5), belongs to the cyclin-dependent kinase family. It is most active in the central nervous system and plays an important role in the regulation of cytoskeletal function. CDK5 expression has been observed in testis, kidney, and ovary with higher levels seen in postmitotic neurons in developing and adult nervous systems. Mutations in CDK5 have been associated with Alzheimer's disease, Parkinson's disease, and ALS, suggesting that CDK5 may play a key role in several neurodegenerative disorders.
    产品信息
    格式 Purified
    控制
    • HeLa cell lysate
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Cdk5 Antibody, clone 1H3 detects level of Cdk5 & has been published & validated for use in WB, IC, IH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    • Immunocytochemistry
    应用说明 Immunocytochemistry Analysis: This antibody has been shown to detect CDK5 in mouse brain histological sections. (Legace, D.C., et al. (2008). Proc Natl Acad Sci USA. 105:18567-18571.)
    生物信息
    免疫原品种 Human CDK5 cross linked to homogenized surgical suture material
    克隆 1H3
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes CDK5.
    同种型 IgG1κ
    品种反应性 RatHumanMouse
    Species Reactivity Note Demonstrated to react with human. Predicted to react with mouse and rat based on 100% sequence homology.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_004926
    基因符号
    • PSSALRE
    • CDK5
    纯化方法 Protein G purfied
    UniProt编号
    • Q00535
    UniProt汇总 FUNCTION: Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. Also interacts with p35 which activates the kinase.

    SIZE: 292 amino acids; 33304 Da

    SUBUNIT: Heterodimer of a catalytic subunit and a regulatory subunit (p35). Found in a trimolecular complex with CABLES1 and ABL1. Interacts with CABLES1 (By similarity). Interacts with AATK.

    SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, growth cone (By similarity). Note=In axonal growth cone with extension to the peripheral lamellipodia (By similarity).

    SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain. ... hide » see more »
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa cell lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected CDK5 on 10 µg of HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABS50,Anti-Cdk5 Antibody, clone 1H3

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