merck millipore,默克密理愽
  • merck millipore,默克密理博,567750,Splitomicin - CAS 1384339 - Calbiochem

  • merck millipore,默克密理博,567750,Splitomicin - CAS 1384339 - Calbiochem

    产品名称：Splitomicin - CAS 1384339 - Calbiochem
    产品型号：567750
    A cell-permeable lactone derived from β-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC₅₀ = 60 µM).

    merck millipore,默克密理博,567750,Splitomicin - CAS 1384339 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,567750,Splitomicin - CAS 1384339 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₃H₁₀O₂5690-03-9
    描述
    概述 A cell-permeable lactone derived from β-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC50 = 60 µM). It creates a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.
    产品目录编号 567750
    品牌系列 Calbiochem®
    同义词 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
    参考
    参考 Bedalov, A., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 15113.
    产品信息
    CAS号 5690-03-9
    具有ATP竞争性 N
    形式 Off-white powder
    Hill配方 C₁₃H₁₀O₂
    化学配方 C₁₃H₁₀O₂
    Molar Mass 198.2
    可逆 N
    结构配方图像
    生物信息
    主靶 NAD+-dependent histone deacetylase activity of Sir2 protein
    主靶IC50 60 µM against NAD+-dependent histone deacetylase activity of Sir2 protein
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,567750,Splitomicin - CAS 1384339 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,528315,PIPPS - CAS 5625-56-9 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,HTS070RTA,Ready-to-Assay™ ETA Endothelin Receptor Frozen Cells


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