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品种反应性 主要应用 宿主 格式 抗体类型 Rb, H, M, R IHC, WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB3794 Replaces 04-581 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Paxillin Antibody 产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in PBS with 50% Glycerol and 0.01% sodium azide, pH 7.3. 应用 应用 Detect Paxillin using this Anti-Paxillin Antibody validated for use in IP, WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Western blot: 1:1,000 on mouse brain lysates.
Immunohistochemistry: 1:10.
Immunoprecipitation: 5 μL/mL lysate
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Recombinant human paxillin. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Paxillin 品种反应性 RabbitHumanMouseRat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002859.1
基因符号 - FLJ16691
- PXN
- Paxillin.
- paxillin
UniProt编号 - P49023
UniProt汇总 FUNCTION: SwissProt: P49023 # Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
SIZE: 591 amino acids; 64533 Da
SUBUNIT: Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1 (By similarity). Binds DDEF2. Interacts with unphosphorylated ITGA4. Interacts with RNF5.
PTM: Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens.
SIMILARITY: SwissProt: P49023 ## Belongs to the paxillin family. & Contains 4 LIM zinc-binding domains.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µL
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