merck millipore,默克密理愽
  • merck millipore,默克密理博,MABS474,Anti-GRP78 Antibody, clone N88

  • merck millipore,默克密理博,MABS474,Anti-GRP78 Antibody, clone N88

    产品名称：Anti-GRP78 Antibody, clone N88
    产品型号：MABS474
    This Anti-GRP78 Antibody, clone N88 is validated for use in western blotting, activity assay & flow cytometry for the detection of GRP78.

    merck millipore,默克密理博,MABS474,Anti-GRP78 Antibody, clone N88

  • 产品介绍
  • merck millipore,默克密理博,MABS474,Anti-GRP78 Antibody, clone N88

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HFC, WB, ACTMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABS474
    描述 Anti-GRP78 Antibody, clone N88
    Alternate Names
    • BiP
    • 78 kDa glucose-regulated protein
    • GRP-78
    • Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
    • Heat shock 70 kDa protein 5
    • Immunoglobulin heavy chain-binding protein
    背景信息 The gene HSPA5 encodes a protein named GRP-78 (78 kDa glucose-regulated protein) also known as BiP (immunoglobulin heavy chain-binding protein) or heat shock 70 kDa protein 5. While originally discovered as one of set of genes that were induced upon cellular starvation and stress, HSPA5 encoded GRP-78 is now known to be an important member of the heat-shock family of proteins. The HSPA5 encoded GRP-78 protein appears to play a role in helping in the assembly of multimeric protein complexes in the endoplasmic reticulum (ER). Cellular localization is in the endoplasmic reticulum lumen and appears as cytoplasmic-like staining. The HSPA5 encoded protein is an essential component of the translocation processes within the endoplasmic reticulum and also functions in the retrograde transport across the ER membrane of incorrectly folded proteins destined to be degraded by the ubiquitin proteasome system. The HSPA5 encoded protein, while widely expressed in all cells types under normal conditions, is particularly induced under conditions of cellular stress, heat, or toxins and conditions which lead to the accumulation of unfolded proteins in the ER.
    产品信息
    格式 Purified
    演示 Purified mouse monoclonal IgG1κ in buffer containing PBS without preservatives.
    应用
    应用 This Anti-GRP78 Antibody, clone N88 is validated for use in western blotting, activity assay & flow cytometry for the detection of GRP78.
    主要应用
    • Flow Cytometry
    • Western Blotting
    • Activity Assay
    应用说明 Activity Assay Analysis: This antibody accelerates tumor growth in a B16F1 melanoma Flank tumor model (de Ridder, G. G., et al. (2012). Melanoma Research. 22(3):225-235).
    Flow Cytometry Analysis: A representative lot detected GRP78 in B16F1 cells (de Ridder, G. G., et al. (2012). Melanoma Research. 22(3):225-235).
    生物信息
    免疫原品种 Recombinant protein corresponding to human GRP78.
    克隆 N88
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 MouseHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_005338
    基因符号
    • GRP78
    • HSPA5
    纯化方法 Protein G purified
    UniProt编号
    • P11021
    产品使用声明
    质量保证 Evaluated by Western Blotting in HeLa cell lysate.

    Western Blotting Analysis: 1.0 µg/mL of this antibody detected GRP78 in 10 µg of HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABS474,Anti-GRP78 Antibody, clone N88

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