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品种反应性 主要应用 宿主 格式 抗体类型 H ICC, WB M Ascites Monoclonal Antibody 描述 产品目录编号 05-916 品牌系列 Upstate
商名 - Upstate
描述 Anti-P-Cadherin Antibody, clone 6A9 产品信息 格式 Ascites 应用 应用 This Anti-P-Cadherin Antibody, clone 6A9 is validated for use in IP, WB, IC for the detection of P-Cadherin. 主要应用 - Immunocytochemistry
- Western Blotting
生物信息 免疫原品种 P-Cadherin extracellular domain purified from A431 cell membranes. 克隆 clone 6A9 宿主 Mouse 特异性 Recognizes P-Cadherin 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_001793
Entrez基因汇总 This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. 基因符号 - PCAD
- CDH3
- P-cadherin
- Placental-cadherin
- HJMD
- CDHP
纯化方法 Ascites UniProt编号 - P22223
UniProt汇总 FUNCTION: SwissProt: P22223 # Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
SIZE: 829 amino acids; 91418 Da
SUBUNIT: Interacts with CDCP1.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Expressed in some normal epithelial tissues and in some carcinoma cell lines.
DISEASE: SwissProt: P22223 # Defects in CDH3 are the cause of hypotrichosis with juvenile macular dystrophy (HJMD) [MIM:601553]. HJMD is a rare autosomal recessive disorder characterized by early hair loss heralding severe degenerative changes of the retinal macula and culminating in blindness during the second to third decade of life. & Defects in CDH3 are the cause of EEM syndrome [MIM:225280]; also known as ectodermal dysplasia, ectrodactyly, and macular dystrophy or Albrectsen-Svendsen syndrome or Ohdo- Hirayama-Terawaki syndrome.
SIMILARITY: SwissProt: P22223 ## Contains 5 cadherin domains.产品使用声明 质量保证 Routinely evaluated by immunoblot on A431 cell lysates. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment 包装信息 数量 100 µL
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