merck millipore,默克密理愽
  • merck millipore,默克密理博,MABS461,Anti-Neutrophil Elastase Antibody, clone AHN-10

  • merck millipore,默克密理博,MABS461,Anti-Neutrophil Elastase Antibody, clone AHN-10

    产品名称：Anti-Neutrophil Elastase Antibody, clone AHN-10
    产品型号：MABS461
    Detect Elastase using this mouse monoclonal antibody, Anti-Neutrophil Elastase Antibody, clone AHN-10 validated for use in ICC, IHC, IP, Radioimmunoassay & Inhibition.

    merck millipore,默克密理博,MABS461,Anti-Neutrophil Elastase Antibody, clone AHN-10

  • 产品介绍
  • merck millipore,默克密理博,MABS461,Anti-Neutrophil Elastase Antibody, clone AHN-10

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABS461
    描述 Anti-Neutrophil Elastase Antibody, clone AHN-10
    Alternate Names
    • PMN elastase
    • Neutrophil elastase
    • Bone marrow serine protease
    • Elastase-2
    • Human leukocyte elastase
    • HLE
    • Medullasin
    背景信息 Neutrophil Elastase, also known as Bone marrow serine protease, Elastase-2, Human leukocyte elastase (HLE), Medullasin or PMN elastase, and encoded by the gene ELANE/ELA2, is a serine proteinase in the same family as chymotrypsin. Neutrophil Elastase has broad substrate specificity and is part of our host defense mechanism against bacteria. Unfortunately passively released or actively secreted elastase from neutrophils has been linked to the pathologic processes of a variety of inflammatory diseases, including idiopathic pulmonary fibrosis, rheumatoid arthritis, adult respiratory distress syndrome, and cystic fibrosis. Neutrophil Elastase is localized to the cytoplasm in granules. Neutrophil Elastase is expressed in neutrophils and macrophages. Defects in Neutrophil Elastase may be associated with cyclic neutropenia and congential neutropenia diseases where neutrophils fail to mature leaving the patient very vunderable to infections.
    产品信息
    格式 Purified
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect Elastase using this mouse monoclonal antibody, Anti-Neutrophil Elastase Antibody, clone AHN-10 validated for use in ICC, IHC, IP, Radioimmunoassay & Inhibition.
    主要应用
    • Immunohistochemistry
    • Immunocytochemistry
    应用说明 Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Neutrophil Elastase in unirradiated and irradiated human and mouse skin tissues (Rhodes, L. E., et al. (2009). FASEB J. 23(11): 3947-3956.; Nicolaou, A., et al. (2012). Photochem Photobiol Sci. 11(2):371-380.; Rutter, J. J., et al. (2009). 129(12):2861-2867.).

    Western Blotting Analysis: A representative lot from an independent laboratory detected Neutrophil Elastase in human pancreatic tissue lysate (Mayerle, J., et al. (2005). Gastroenterology. 129(4):1251-1267.).

    Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated Neutrophil Elastase in human pancreatic tissue lysate (Mayerle, J., et al. (2005). Gastroenterology. 129(4):1251-1267.).

    Immunocytochemistry Analysis: A representative lot from an independent laboratory detected Neutrophil Elastase in human acinar cells (Mayerle, J., et al. (2005). Gastroenterology. 129(4):1251-1267.).

    Inhibition Analysis: This assay inhibits the elastinolytic actiity of purified human Neutrophil Elastase (Skubitz, K., et al. (1988). J Leukoc Biol. 44(3):158-165.).

    Radioimmunoassay Analysis: A representative lot from an independent laboratory detected Neutrophil Elastase using purified Neutrophil Elastase (Skubitz, K., et al. (1988). J Leukoc Biol. 44(3):158-165.).
    生物信息
    免疫原品种 Whole cells corresponding to human Neutrophil Elastase.
    克隆 AHN-10
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody detects with human Neutrophil Elastase but not other major neutrophil proteases: Cathapsin G, proteinase 3, collagenase, or esterase N (Skubitz, K. M., et al. (1988). J Leukoc Biol. 44(3):158-165.).
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001963.1
    基因符号
    • ELA2
    • ELANE
    纯化方法 Protein G purified
    UniProt编号
    • P08246
    产品使用声明
    质量保证 Evaluated by Immunocytochemistry Analysis in peripheral blood mononuclear cells.

    Immunocytochemistry Analysis: A 1:250 dilution of this antibody detected Neutrophil Elastase in peripheral blood mononuclear cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABS461,Anti-Neutrophil Elastase Antibody, clone AHN-10

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