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merck millipore,默克密理博,513000,PD 98059 - CAS 167869-21-8 - Calbiochem
产品名称：PD 98059 - CAS 167869-21-8 - Calbiochem
产品型号：513000
Selective, reversible, and cell-permeable inhibitor of MAP kinase kinase (MEK) that acts by inhibiting the activation of MAP kinase and subsequent phosphorylation of MAP kinase substrates.
merck millipore,默克密理博,513000,PD 98059 - CAS 167869-21-8 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₆H₁₃NO₃ 167869-21-8 描述 概述 Selective, reversible, and cell-permeable inhibitor of MAP kinase kinase (MEK) that acts by inhibiting the activation of MAP kinase and subsequent phosphorylation of MAP kinase substrates. Pretreatment of PC-12 cells with PD 98059 completely blocks the 4-fold increase in MAP kinase activity produced by nerve growth factor (NGF; IC50 = 2 µM); however, it has no effect on NGF-dependent tyrosine phosphorylation of the p140trk receptor or its substrate Shc and does not block NGF-dependent activation of PI 3-kinase. Blocks LPS-induced activation of TNF-α gene expression. Inhibits cell growth and reverses the phenotype of ras-transformed BALB3T3 mouse fibroblasts and rat kidney cells. A 5 mg/ml solution of PD 98059 (Cat. No. 513001) in anhydrous DMSO is also available. 产品目录编号 513000 品牌系列 Calbiochem®
同义词 2ʹ-Amino-3ʹ-methoxyflavone, MEK Inhibitor V 参考 参考 Means, T.K., et al. 2000. J. Leukoc. Biol. 67, 885.
Kültz, D., et al. 1998. J. Biol. Chem. 273, 13645.
Dudley, D.T., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 7686.
Langlois, W.J., et al. 1995. J. Biol. Chem. 270, 25320.
Pang, L., et al. 1995. J. Biol. Chem. 270, 13585.
Waters, S.B., et al. 1995. J. Biol. Chem. 270, 20883.产品信息 CAS号 167869-21-8 具有ATP竞争性 N 形式 Pale yellow solid Hill配方 C₁₆H₁₃NO₃ 化学配方 C₁₆H₁₃NO₃ Molar Mass 267.3 可逆 Y 结构配方图像 生物信息 主靶 MAP kinase kinase (MEK) 主靶IC50 2 µM against NGF-induced increase in MAP kinase activity 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO or MeOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
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