merck millipore,默克密理愽
  • merck millipore,默克密理博,MABE271,Anti-GATA3 Antibody, clone 3F1.1

  • merck millipore,默克密理博,MABE271,Anti-GATA3 Antibody, clone 3F1.1

    产品名称：Anti-GATA3 Antibody, clone 3F1.1
    产品型号：MABE271
    Anti-GATA3 Antibody, clone 3F1.1 is a mouse monoclonal antibody for detection of GATA3 also known as Trans-acting T-cell-specific transcription factor GATA-3, GATA-binding factor 3 & has been validate More>>

    merck millipore,默克密理博,MABE271,Anti-GATA3 Antibody, clone 3F1.1

  • 产品介绍
  • merck millipore,默克密理博,MABE271,Anti-GATA3 Antibody, clone 3F1.1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABE271
    描述 Anti-GATA3 Antibody, clone 3F1.1
    Alternate Names
    • GATA-binding factor 3
    • Trans-acting T-cell-specific transcription factor GATA-3
    背景信息 GATA3 is a transcription factor containing a zinc finger domain. GATA3 is primarily expressed in T cells, where it thought to participate in T-cell receptor gene activation through binding to enhancers. Analysis of conditional GATA3 knockout mice confirmed the critical role of GATA3 in helper T cell differentiation and proliferation. Cells expressing GATA3 develop the profile of Th2 cells, secreting IL-4, IL-5 and IL-13. Binding of GATA3 in the regulatory regions of the genes of these cytokines alters chromatin structure, increasing accessibility to other transcription factors. T cell receptor activation activates NFAT and other transcription factors that cooperate with GATA3 in inducing Th2 cell differentiation. Blocking GATA3 action has been suggested as a therapeutic strategy to treat asthma. GATA3 has also been implicated in developmental processes such as the development of the inner ear.
    产品信息
    格式 Purified
    控制
    • Jurkat cell lysate.
    演示 Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
    应用
    应用 Anti-GATA3 Antibody, clone 3F1.1 is a mouse monoclonal antibody for detection of GATA3 also known as Trans-acting T-cell-specific transcription factor GATA-3, GATA-binding factor 3 & has been validated in WB, FC.
    主要应用
    • Flow Cytometry
    • Western Blotting
    应用说明 Flow Cytometry Analysis: 1 µg from a representative lot detected GATA3 in Jurkat cells.
    生物信息
    免疫原品种 Recombinant protein corresponding to human GATA3.
    克隆 3F1.1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgMκ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001002295
    Entrez基因汇总 This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia.
    基因符号
    • GATA3
    纯化方法 Purified by ion-exchange chromatography
    UniProt编号
    • P23771
    UniProt汇总 FUNCTION: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'.

    SUBCELLULAR LOCATION: Nucleus.

    TISSUE SPECIFICITY: T-cells and endothelial cells.
    产品使用声明
    质量保证 Evaluated by Western Blot in Jurkat cell lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected GATA3 in 10 µg of Jurkat cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABE271,Anti-GATA3 Antibody, clone 3F1.1

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