merck millipore,默克密理博,MABS168,Anti-Dab2 Antibody, clone EP2297Y, Rabbit,MABS168

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merck millipore,默克密理博,MABS168,Anti-Dab2 Antibody, clone EP2297Y, Rabbit,MABS168
产品名称：Anti-Dab2 Antibody, clone EP2297Y, Rabbit, MABS168
产品型号：MABS168

merck millipore,默克密理博,MABS168,Anti-Dab2 Antibody, clone EP2297Y, Rabbit,MABS168

产品介绍

merck millipore,默克密理博,MABS168,Anti-Dab2 Antibody, clone EP2297Y, Rabbit,MABS168

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	FC, WB, ICC	Rb	Diluted Culture Supernatant	Monoclonal Antibody

描述
产品目录编号	MABS168
描述	Anti-Dab2 Antibody, clone EP2297Y, Rabbit \| MABS168
Alternate Names	mitogen-responsive phosphoprotein disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) Differentially-expressed protein 2 disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein) disabled homolog 2
背景信息	Disabled-2 (Dab2) is a component of the CSF-1 signal transduction pathway. Dab2 is involved in the regulation of cytoskeleton based functions by regulating cell positioning, inducing marcrophage adhesion, or regulation of protein trafficking of endocytosis involved proteins (1,2). Dab2 has been implicated in regulating the homeostasis of epithelial differentiation, where Dab2 is involved in endodermal cell formation, differentiation, and organization. Dab2 mRNA expression is common in normal ovarian epithelia cells but low or lack of expression is seen in ovarian carcinoma cell lines (3).

产品信息
格式	Diluted Culture Supernatant
控制	Human pancreas tissue lysate
演示	Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

应用
主要应用	Flow Cytometry Western Blotting Immunocytochemistry
应用说明	Immunocytochemistry Analysis: A 1:100-1:250 dilution from a representative lot was used in IC. Immunoprecipitation Analysis: A 1:20 dilution from a representative lot was used in IP. Flow Cytometry Analysis: A 1:50 dilution from a representative lot was used in FC.

生物信息
免疫原品种	Synthetic peptide corresponding to human Dab2 at the C-terminus.
表位	C-terminus
克隆	EP2297Y
宿主	Rabbit
特异性	This antibody recognizes Dab2 at the C-terminus.
同种型	IgG
品种反应性	Human
Species Reactivity Note	Demonstrated to react with Human.
抗体类型	Monoclonal Antibody
Entrez基因编号	P98082
基因符号	OTTHUMP00000221142 DOC-2 DOC2 FLJ26626
纯化方法	Unpurified
UniProt编号	P98082
UniProt汇总	FUNCTION: Component of the CSF-1 signal transduction pathway By similarity. SUBUNIT STRUCTURE: Interacts with the globular tail of MYO6. Interacts with DAB2IP. Interacts with NOSTRIN By similarity. SUBCELLULAR LOCATION: Cytoplasmic vesicle › clathrin-coated vesicle membrane. Membrane › clathrin-coated pit. Note: Colocalizes with large insert-containing isoforms of MYO6 at clathrin-coated pits/vesicles. TISSUE SPECIFICITY: Expressed in deep invaginations, inclusion cysts and the surface epithelial cells of the ovary. Also expressed in breast epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, lung epithelial cells, placenta, brain stem, heart and small intestine. SEQUENCE SIMILARITIES: Contains 1 PID domain.

产品使用声明
质量保证	Evaluated by Western Blot in human pancreas tissue lysate. Western Blot Analysis: A 1:2,000 dilution of this antibody detected Dab2 in human pancreas tissue lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.