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经验配方 CAS号 C₂₂H₂₄N₂O₈ · HCl · 1/2(H₂O) · 1/2(C₂H₆O) 24390-14-5 描述 概述 A commonly-used broad-spectrum antibiotic. A potent inhibitor of MMP-8 (neutrophil collagenase; IC50 = 30 µM) relative to MMP-1 (interstitial collagenase; IC50 = 300 µM). Also inhibits collagen synthesis by bovine articular chondrocytes cultured in alginate (IC50 = 25 µM). Inhibits nitric oxide synthesis by LPS-activated macrophages without affecting IL-10 release. 产品目录编号 324385 品牌系列 Calbiochem®
同义词 α-6-Deoxy-5-hydroxytetracycline, Vibramycin, Hyclate 参考 参考 D’Agostino, P., et al. 1998. J. Infect. Dis. 177, 489.
Beekman, B., et al. 1997. Biochem. Biophys. Res. Commun. 237, 107.
Hanemaaijer, R., et al. 1997. J. Biol. Chem. 272, 31504.
Lauhio, A., et al. 1994. Clin. Exp. Immunol. Antimicrobiol. Agents Chemother. 36, 227.
Sorsa, T., et al. 1994. Ann. N.Y. Acad. Sci. 732, 112.
Suomalainen, K., et al. 1992. Antimicrobiol. Agents Chemother. 36, 227.产品信息 CAS号 24390-14-5 具有ATP竞争性 N 形式 Light yellow crystalline solid Hill配方 C₂₂H₂₄N₂O₈ · HCl · 1/2(H₂O) · 1/2(C₂H₆O) 化学配方 C₂₂H₂₄N₂O₈ · HCl · 1/2(H₂O) · 1/2(C₂H₆O) Molar Mass 512.9 吸湿 Hygroscopic
可逆 N 结构配方图像 生物信息 主靶 MMP-8 主靶IC50 30 µM against MMP-8 (neutrophil collagenase); 25 µM inhibiting collagen synthesis by bovine articular chondrocytes cultured in alginate 纯度 ≥95% by TLC 理化信息 细胞可渗透 N 溶解度 H₂O GHS安全信息 RTECS QI8925000 安全信息 R相 R: 20/21/22-63
Harmful by inhalation, in contact with skin and if swallowed.
Possible risk of harm to the unborn child.S相 S: 22-36
Do not breathe dust.
Wear suitable protective clothing.储存和货运信息 货运代码 Ambient Temperature Only
毒性 Harmful & Carcinogenic / Teratogenic
储存 +2°C to +8°C
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Follwing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 5 days at 4°C.
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