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merck millipore,默克密理博,MAB2250Z,Anti-Integrin β1 Antibody, clone 21C8, azide free
产品名称：Anti-Integrin β1 Antibody, clone 21C8, azide free
产品型号：MAB2250Z
This Anti-Integrin β1 Antibody, clone 21C8, azide free is validated for use in FC, IP, FUNC, IH for the detection of Integrin β1.
merck millipore,默克密理博,MAB2250Z,Anti-Integrin β1 Antibody, clone 21C8, azide free
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, FC M Purified Monoclonal Antibody 描述 产品目录编号 MAB2250Z 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Integrin β1 Antibody, clone 21C8, azide free Alternate Names - MAB2250
- CD29
产品信息 格式 Purified 演示 Purified immunoglobilin. Liquid in PBS, no preservatives. 应用 应用 This Anti-Integrin β1 Antibody, clone 21C8, azide free is validated for use in FC, IP, FUNC, IH for the detection of Integrin β1. 主要应用 - Immunohistochemistry
- Flow Cytometry
应用说明 Immunoprecipitation
Immunohistochemistry on frozen sections
Flow cytometry
Stimulates adhesion of cells to extracellular matrix proteins (Wilkins et al., 1996)
Does not bind reduced beta1 integrin on Western blot
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 source is Jurkat T-leukemic cell line 克隆 21C8 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Reacts with the human integrin beta1 subunit. Specificity verified by preclearing of beta1in immunoprecipitation, flow cytometry on transfectant cells displaying human beta1 integrin, and reactivity with purified beta1. Recognizes distinct elements within the same epitope cluster bound by MAB2251.(Wilkins et al., 1996) 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002292.3
基因符号 - LAMS
- LAMB2
- S-laminin
UniProt编号 - P55268
UniProt汇总 FUNCTION: SwissProt: P55268 # Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
SIZE: 1798 amino acids; 195981 Da
SUBUNIT: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-2 is a subunit of laminin-3 (S-laminin), laminin-4 (S- merosin), and laminin-7 (KS-laminin).
SUBCELLULAR LOCATION: Secreted, extracellular space. Note=S- laminin is concentrated in the synaptic cleft of the neuromuscular junction.
DOMAIN: SwissProt: P55268 The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. & Domains VI and IV are globular.
DISEASE: SwissProt: P55268 # Defects in LAMB2 are the cause of Pierson syndrome [MIM:609049]; also known as microcoria-congenital nephrotic syndrome. Pierson syndrome is characterized by nephrotic syndrome with neonatal onset, diffuse mesangial sclerosis and eye abnormalities with microcoria as the leading clinical feature. Death usually occurs within the first weeks of life. Disease severity depends on the mutation type: nontruncating LAMB2 mutations may display variable phenotypes ranging from a milder variant of Pierson syndrome to isolated congenital nephrotic syndrome. & Defects in LAMB2 are a cause of congenital nephrotic syndrome [MIM:609049]. Congenital nephrotic syndrome constitutes a heterogeneous group of conditions having in common the disruption of normal glomerular permselectivity. Congenital nephrotic syndrome due to LAMB2 mutations may be associated with ocular abnormalities.
SIMILARITY: Contains 13 laminin EGF-like domains. & Contains 1 laminin IV type B domain. & Contains 1 laminin N-terminal domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Aliquot using sterile technique and maintain at 2-8°C. 包装信息 数量 100 µg
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