merck millipore,默克密理博,MABN616,Anti-Potassium Channel Kv1.2 Antibody, clone K36/15

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
R, M	IHC, WB	M	Purified	Monoclonal Antibody

描述
产品目录编号	MABN616
描述	Anti-Potassium Channel Kv1.2 Antibody, clone K36/15
Alternate Names	Voltage-gated potassium channel subunit Kv1.1 Potassium voltage-gated channel subfamily A member 1 RBKI RCK1
背景信息	Potassium voltage-gated channel subfamily A member 1, better known as Potassium Channel Kv1.2, Kv1.1, or Kcna1 belongs to the Shaker potassium channel group responsible for mediating ion permeability of excitable membranes. Conformational changes as a result of voltage changes across the cell membrane varies the permeability of this multi-pass transmembrane channel to potassium. Mutations of the Shaker potassium channel gene in Drosophila and the KCNA1 gene for its mammalian orthologue, Kv1.1, reduce the probability of action potential failure thereby causing hyperexcitability near axon branch points and nerve terminals, thereby leading to uncontrolled movements and recapitulating the episodic ataxia-1 (EA1) symptoms in human patients. Further, the axonal Kv1 channel activity may regulate synaptic transmission by modulating the action potential waveform, duration, firing pattern, and spread of depolarization into axonal branches.

产品信息
格式	Purified
控制	Mouse brain tissue lysate
演示	Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Anti-Potassium Channel Kv1.2 Antibody, clone K36/15 is a highly specific mouse monoclonal antibody, that targets Kv1.2 & has been tested in western blotting, Immunofluorescence & IHC.
主要应用	Immunohistochemistry Western Blotting
应用说明	Western Blotting Analysis: 4 µg/mL from a representative lot detected Potassium Channel Kv1.2 in 10 µg of rat brain membrane tissue lysate. Immunofluoresense Analysis: A representative lot from an independent laboratory detected Potassium Channel Kv1.2 in Kv1.1 transfected COS-1 cells (Tiffany, A. M., et al. (2000). J Cell Biol. 148(1):147-158.). Immunhistochemistry Analysis: A representative lot from an independent laboratory detected Potassium Channel Kv1.2 in Kv1.1 transfected COS-1 cells (Wenzel. H. J., et al (2007). Epilepsia. 48(11):2023-2046.). Immunohistochemistry Analysis: A representative lot from an independent laboratory detect Potassium Channel Kv1.2 in wild type mouse hippocampus tissue, and demonstrated a loss of signal in Potassium Channel Kv1.2 knock out mouse hippocampus tissue (Prof. J. Trimmer, University of California, Davis.).

生物信息
免疫原品种	Linear peptide corresponding to rat Potassium Channel Kv1.2.
克隆	K36/15
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
同种型	IgG2bκ
品种反应性	RatMouse
Species Reactivity Note	Demonstrated to react with Mouse and Rat. Other homologies: Human (94% sequence homology).
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_775118
基因符号	Kcna1
纯化方法	Protein G purified
UniProt编号	P10499

产品使用声明
质量保证	Evaluated by Western Blotting in mouse brain tissue lysate. Western Blotting Analysis: 2 µg/mL of this antibody detected Potassium Channel Kv1.2 in 10 µg of mouse brain tissue lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,MABN616,Anti-Potassium Channel Kv1.2 Antibody, clone K36/15

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