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merck millipore,默克密理博,MAB3069,Anti-Connexin 32 Antibody, clone M12.13
产品名称：Anti-Connexin 32 Antibody, clone M12.13
产品型号：MAB3069
Anti-Connexin 32 Antibody, clone M12.13 detects level of Connexin 32 & has been published & validated for use in WB, IH.
merck millipore,默克密理博,MAB3069,Anti-Connexin 32 Antibody, clone M12.13
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB3069 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Connexin 32 Antibody, clone M12.13 Alternate Names - Cx32
产品信息 格式 Purified 演示 Liquid in 0.02M PB, 0.25M NaCl, containing 0.1% sodium azide. 应用 应用 Anti-Connexin 32 Antibody, clone M12.13 detects level of Connexin 32 & has been published & validated for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry: acetone or unfixed tissues recommended. Epitope is internal, paraffin sections are untested.
Works with lightly formaldehyde-fixed tissue.
Western blot: Detects a 27 kDa Connexin 32 polypeptide in blots of rat hepatocyte gap junctions and an additional 47 kDa band corresponding to aggregates.
Optimal working dilutions must be determined by end user.生物信息 克隆 M12.13 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Monoclonal antibody MAB3069 was produced by the immunization of BALB/c mice with isolated rat junctional complexes, prepared by the method of Stevenson and Goodenough (1988). Epitope mapping, hydropathy plotting, and topological studies suggest that this antibody is very likely directed against an epitope located between residues 95-125 in the central cytoplasmic loop of rat Cx32. 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_001097642.1
- NM_000166.4
Entrez基因汇总 Connexins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells (Bergoffen et al., 1993 [PubMed 8266101]). For a general discussion of connexin proteins, see GJB2 (MIM 121011).[supplied by OMIM] 基因符号 - CMTX
- GJB1
- Connexin-32
- CX32
- CMTX1
- Cx32
UniProt编号 - P08034
UniProt汇总 FUNCTION: SwissProt: P08034 # One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
SIZE: 283 amino acids; 32025 Da
SUBUNIT: A connexon is composed of a hexamer of connexins.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
DISEASE: SwissProt: P08034 # Defects in GJB1 are the cause of Charcot-Marie-Tooth disease X-linked type 1 (CMTX1) [MIM:302800]; also designated CMT- X. CMTX1 is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot- Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies characterized by severely reduced motor nerve conduction velocities (NCVs) (less than 38m/s) and segmental demyelination and remyelination, and primary peripheral axonal neuropathies characterized by normal or mildly reduced NCVs and chronic axonal degeneration and regeneration on nerve biopsy. CMTX1 has both demyelinating and axonal features. Central nervous system involvement may occur. & Defects in GJB1 may contribute to the phenotype of Dejerine-Sottas syndrome (DSS) [MIM:145900]; also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS is a severe degenerating neuropathy of the demyelinating Charcot-Marie-Tooth disease category, with onset by age 2 years. DSS is characterized by motor and sensory neuropathy with very slow nerve conduction velocities, increased cerebrospinal fluid protein concentrations, hypertrophic nerve changes, delayed age of walking as well as areflexia. There are both autosomal dominant and autosomal recessive forms of Dejerine- Sottas syndrome.
SIMILARITY: SwissProt: P08034 ## Belongs to the connexin family. Beta-type (group I) subfamily.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in convenient undiluted aliquots for up to 6 months. 包装信息 数量 100 µg
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