merck millipore,默克密理愽
  • merck millipore,默克密理博,MABN31,Anti-alpha B-crystallin Antibody, clone CPTC-CRYAB-1

  • merck millipore,默克密理博,MABN31,Anti-alpha B-crystallin Antibody, clone CPTC-CRYAB-1

    产品名称：Anti-alpha B-crystallin Antibody, clone CPTC-CRYAB-1
    产品型号：MABN31
    Detect alpha B-crystallin using this Anti-alpha B-crystallin Antibody, clone CPTC-CRYAB-1 validated for use in WB.

    merck millipore,默克密理博,MABN31,Anti-alpha B-crystallin Antibody, clone CPTC-CRYAB-1

  • 产品介绍
  • merck millipore,默克密理博,MABN31,Anti-alpha B-crystallin Antibody, clone CPTC-CRYAB-1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABN31
    描述 Anti-alpha B-crystallin Antibody, clone CPTC-CRYAB-1
    Alternate Names
    • Alpha(B)-crystallin
    • crystallin, alpha B
    • alpha(B)-crystallin
    • heat-shock 20 kD like-protein
    • alpha-crystallin B chain
    • Rosenthal fiber component
    • alpha crystallin B chain
    • Renal carcinoma antigen NY-REN-27
    • alpha B crystallin
    • Heat shock protein beta-5
    背景信息 Alpha B-crystallin is a heat shock chaperone protein, up-regulated by stress. It has been shown to be expressed in the vertebrate eye lens and also found in cardiac and skeletal muscles, the kidney and the brain. Alpha B-crystallin is also found to be a component of Rosenthal fibers and a consistent tissue marker of epileptic foci.
    产品信息
    格式 Purified
    控制
    • Human heart tissue lysate
    演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect alpha B-crystallin using this Anti-alpha B-crystallin Antibody, clone CPTC-CRYAB-1 validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Full length recombinant protein corresponding to human alpha B-crystallin.
    Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program.
    克隆 CPTC-CRYAB-1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG2aκ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001876
    Entrez基因汇总 Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. [provided by RefSeq].
    基因符号
    • HSPB5
    • CRYAB
    • CTPP2
    • HspB5
    • Bcrystallin
    • CRYA2
    纯化方法 Protein G
    UniProt编号
    • P02511
    UniProt汇总 FUNCTION: May contribute to the transparency and refractive index of the lens.

    SUBUNIT STRUCTURE: Homodimer. Aggregates with homologous proteins, including CRYAA and the small heat shock protein HSPB1, to form large heteromeric complexes. Interacts with HSPBAP1 and TTN/titin.

    SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note: Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.

    TISSUE SPECIFICTY: Lens as well as other tissues.

    INVOLVEMENT IN DISEASE: Defects in CRYAB are the cause of myofibrillar alpha-B crystallin-related (MFM-CRYAB) [MIM:608810]. A neuromuscular disorder that results in weakness of the proximal and distal limb muscles, weakness of the neck, velopharynx and trunk muscles, hypetrophic cardiomyopathy, and cataract in a subset of patients.

    SEQUENCE SIMILARITIES: Belongs to the small heat shock protein (HSP20) family.

    MASS SPECTROMETRY: Molecular mass is 20201 Da from positions 1 - 175. Determined by ESI.

    Molecular mass is 20281 Da from positions 1 - 175. Determined by ESI. With 1 phosphate group.

    Molecular mass is 20360 Da from positions 1 - 175. Determined by ESI. With 2 phosphate groups.

    Molecular mass is 20199 Da from positions 1 - 175. Determined by ESI.

    Molecular mass is 20278 Da from positions 1 - 175. Determined by ESI. With 1 phosphate group.
    产品使用声明
    质量保证 Evaluated by Western Blot in human heart tissue lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected alpha B-crystallin on 10 µg of human heart tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABN31,Anti-alpha B-crystallin Antibody, clone CPTC-CRYAB-1

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