merck millipore,默克密理愽
  • merck millipore,默克密理博,07-513,Anti-PLCε Antibody

  • merck millipore,默克密理博,07-513,Anti-PLCε Antibody

    产品名称：Anti-PLCε Antibody
    产品型号：07-513
    Detect PLCε using this Anti-PLCε Antibody validated for use in WB.

    merck millipore,默克密理博,07-513,Anti-PLCε Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-513,Anti-PLCε Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-513
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-PLCε Antibody
    产品信息
    格式 Affinity Purified
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 5mg/ml BSA, 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 Detect PLCε using this Anti-PLCε Antibody validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 peptide corresponding to amino acids 2285-2303 of human PLCε.
    宿主 Rabbit
    特异性 PLC epsilon
    同种型 IgG
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_016341
    Entrez基因汇总 PLCE1 belongs to the phospholipase family that catalyzes the hydrolysis of polyphosphoinositides such as phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) to generate the second messengers Ins(1,4,5)P3 and diacylglycerol. These products initiate a cascade of intracellular responses that result in cell growth and differentiation and gene expression.[supplied by OMIM]
    基因符号
    • NPHS3
    • PLCE1
    • KIAA1516
    • PLCE
    • PPLC
    • FLJ23659
    • PLC-epsilon-1
    纯化方法 Immunoaffinity chromatography
    UniProt编号
    • Q9P212
    UniProt汇总 FUNCTION: SwissProt: Q9P212 # The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine- exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation.
    COFACTOR: Calcium.
    SIZE: 2302 amino acids; 258715 Da
    SUBUNIT: Interacts with RHOA (By similarity). Interacts with IQGAP1, HRAS, RAP1A, RAP2A, RAP2B and RRAS.
    SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane. Golgi apparatus membrane. Note=Recruited to plasma membrane by activated HRAS and RAP2. Recruited to perinuclear membrane by activated RAP1A. Isoform 1 and isoform 2 associates with Golgi membranes.
    TISSUE SPECIFICITY: Widely expressed. Isoform 1 is broadly expressed and only absent in peripheral blood leukocytes. Isoform 2 is specifically expressed in placenta, lung and spleen.
    DOMAIN: SwissProt: Q9P212 The Ras-associating domain 1 is degenerated and may not bind HRAS. The Ras-associating domain 2 mediates interaction with GTP-bound HRAS, RAP1A, RAP2A and RAP2B and recruitment of HRAS to the cell membrane. & The Ras-GEF domain has a GEF activity towards HRAS and RAP1A. Mediates activation of the mitogen-activated protein kinase pathway.
    DISEASE: SwissProt: Q9P212 # Defects in PLCE1 are the cause of nephrotic syndrome type 3 (NPHS3) [MIM:610725]; also called early-onset nephrotic syndrome type 3. Nephrotic syndrome, a malfunction of the kidney glomerular filter, leads to proteinuria, hypoalbuminemia, edema. End-stage kidney disease is observed in steroid-resistant nephrotic syndrome.
    SIMILARITY: Contains 1 C2 domain. & Contains 1 PI-PLC X-box domain. & Contains 1 PI-PLC Y-box domain. & Contains 2 Ras-associating domains. & Contains 1 Ras-GEF domain.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot in RIPA lysates from human foreskin fibroblast (HFF) cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at -20°C
    包装信息
    数量 200 µL

    merck millipore,默克密理博,07-513,Anti-PLCε Antibody

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