merck millipore,默克密理博,ABN100,Anti-Vesicular Acetylcholine Transporter (VAChT) Antibody

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M, R	ELISA, IHC	Gt	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	ABN100
描述	Anti-Vesicular Acetylcholine Transporter (VAChT) Antibody
Alternate Names	Solute carrier family 18 member 3 Vesicular acetylcholine transporter VAChT rVAT
背景信息	Acetylcholine mediates cholinergic transmission in the central and peripheral nervous systems, and is an important modulator of cognition, movement, and cardiovascular function, among other processes. The effects of acetylcholine are regulated by its synthesis, storage, and breakdown, which involve the related enzymes choline acetyltransferase (ChAT), vesicular acetylcholine transporter (VAChT), and acetylcholinesterase (AChE), respectively. VAChT is primarily found in the membrane of presynaptic secretory vesicles. It contains 12 transmembrane domains and a synaptic-vesicular–targeting signal located on the intracellular C-terminal tail. The primary function of VAChT is to actively transport cytoplasmic ACh, across an electrochemical gradient, into synaptic vesicles that release ACh upon cell stimulation. The VAChT can affect cholinergic signaling by affecting the relative pools of ACh secreted to activate postsynaptic nicotinic and muscarinic receptors. VAChT is phosphorylated on its serine 480 residue in the C-terminal tail by protein kinase C. Although the precise role of this modification is still unclear, previous studies suggest that it may affect the localization of VAChT to synaptic vesicles.

产品信息
格式	Affinity Purified
控制	Vesicular Acetylcholine Transporter (VAChT) peptide
演示	Purified goat polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Anti-Vesicular Acetylcholine Transporter (VAChT) Antibody detects level of Vesicular Acetylcholine Transporter (VAChT) & has been published & validated for use in IHC, ELISA.
主要应用	ELISA Immunohistochemistry
应用说明	Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Vesicular Acetylcholine Transporter (VAChT) in rat midbrain tissue. ELISA Analysis: A representative lot detected Vesicular Acetylcholine Transporter (VAChT) in a direct ELISA using a corresponding peptide.

生物信息
免疫原品种	KLH-conjugated linear peptide corresponding to the C-terminus of rat VAChT.
表位	C-terminus
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Goat
特异性	This antibody recognizes the C-terminus of Vesicular Acetylcholine Transporter (VAChT).
品种反应性	MouseRat
Species Reactivity Note	Demonstrated to react with Rat and Mouse. Other homologies: Human (95% sequence homology).
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_113851
基因符号	Vat Slc18a3 Vacht
纯化方法	Affinity purified
UniProt编号	Q62666

产品使用声明
质量保证	Evaluated by Immunohistochemistry Analysis. Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Vesicular Acetylcholine Transporter (VAChT) in mouse midbrain tissue.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,ABN100,Anti-Vesicular Acetylcholine Transporter (VAChT) Antibody

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