merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB5460,Anti-Nkx2.1 Antibody, clone 8G7-G3-1

  • merck millipore,默克密理博,MAB5460,Anti-Nkx2.1 Antibody, clone 8G7-G3-1

    产品名称：Anti-Nkx2.1 Antibody, clone 8G7-G3-1
    产品型号：MAB5460
    This Anti-Nkx2.1 Antibody is validated for use in WB, IH(P) for the detection of Nkx2.1.

    merck millipore,默克密理博,MAB5460,Anti-Nkx2.1 Antibody, clone 8G7-G3-1

  • 产品介绍
  • merck millipore,默克密理博,MAB5460,Anti-Nkx2.1 Antibody, clone 8G7-G3-1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMAscitesMonoclonal Antibody
    描述
    产品目录编号 MAB5460
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Nkx2.1 Antibody, clone 8G7-G3-1
    Alternate Names
    • Thyroid Transcription Factor-1
    • TTF-1
    产品信息
    格式 Ascites
    演示 Ascites fluid. Liquid. Contains no preservative.
    应用
    应用 This Anti-Nkx2.1 Antibody is validated for use in WB, IH(P) for the detection of Nkx2.1.
    主要应用
    • Western Blotting
    应用说明 Western blot. The antibody reacts with a 40 kDa band in immunoblots of nuclear extracts or whole cell lysates from the Nkx2.1 positive cell lines MLE15, H441-4, H345 and rat type II pmeumocyte cells.

    Immunohistochemistry. The antibody can be used on formalin-fixed paraffin embedded tissue. Heat induced epitope retrieval is recommended.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Recombinant rat Nkx2.1.
    克隆 8G7-G3-1
    宿主 Mouse
    特异性 Nkx2.1 (Thyroid Transcription Factor-1, TTF-1).
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_003317.3
    • NM_001079668.1
    基因符号
    • NKX2A
    • NKX2-1
    • BCH
    • TEBP
    • TITF1
    • TTF1
    • NKX2.1
    • NK-2
    • TTF-1
    • BHC
    UniProt编号
    • P43699
    UniProt汇总 FUNCTION: SwissProt: P43699 # Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis.
    SIZE: 371 amino acids; 38596 Da
    SUBCELLULAR LOCATION: Nucleus.
    TISSUE SPECIFICITY: Thyroid and lung.
    PTM: Phosphorylated on serine residues (By similarity).
    DISEASE: SwissProt: P43699 # Defects in TITF1 are the cause of benign hereditary chorea (BHC) [MIM:118700]; also known as hereditary chorea without dementia. BHC is an autosomal dominant movement disorder. The early onset of symptoms (usully before the age of 5) and the observation that in some BHC families the symptoms tend to decrease in adulthood suggests that the disorder results from a developmental disturbance of the brain. BHC is non-progressive and patients have normal or slightly below normal intelligence. There is considerable inter- and intrafamilial variability, including dysarthria, axial distonia and gait disturbances. & Defects in TITF1 are the cause of choreoathetosis, hypothyroidism, and neonatal respiratory distress (CHNRD) [MIM:610978]. This syndrome include neurological, thyroid, and respiratory problems.
    SIMILARITY: SwissProt: P43699 ## Belongs to the NK-2 homeobox family. & Contains 1 homeobox DNA-binding domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB5460,Anti-Nkx2.1 Antibody, clone 8G7-G3-1

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