- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H, R IHC, FC M Purified Monoclonal Antibody 描述 产品目录编号 MABF72 描述 Anti-TLR3 Antibody, clone 2B11.2 Alternate Names - CD283
- Toll-like receptor 3
背景信息 TLR3 (Toll-like Receptor 3) is a member of the Toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR3 is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of leukocytes. TLR3 recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. TLR3 thus plays a role in host defense against viruses. 产品信息 格式 Purified 控制 - A549 cells
演示 Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. 应用 应用 Anti-TLR3 Antibody, clone 2B11.2 is an antibody against TLR3 for use in FC, IH. 主要应用 - Immunohistochemistry
- Flow Cytometry
应用说明 Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TLR3 in astrocytes and glial cells in rat cerebellum. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human TLR3. 克隆 2B11.2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgMκ 品种反应性 HumanRat Species Reactivity Note Demonstrated to react with Rat and Human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_003256
Entrez基因汇总 The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. 基因符号 - TLR3
纯化方法 Purifed by ion exchange chromatography UniProt编号 - O15455
UniProt汇总 FUNCTION: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
SUBUNIT STRUCTURE: Interacts with MYD88 via their respective TIR domains. Interacts (via transmembrane domain) with UNC93B1. Interacts with TICAM1. Homodimer formation is triggered by ligand binding and is required for TLR3 signaling. Binding of double-stranded RNA is required for the interaction with SRC.
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane.
TISSUE SPECIFICITY: Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons.产品使用声明 质量保证 Evaluated by Flow Cytometry in A549 cells.
Flow Cytometry Analysis: 1 µg of this antibody detected TLR3 in 1X10E6 A549 cells.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,250225,Cytochalasin B, Dihydro- - CAS 39156-67-7 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,HTS036M,ChemiSCREEN™ CCR9 Membrane Preparation
相关产品
merck millipore,默克密理博,ABS449,Anti-UNG1 Antibody
merck millipore,默克密理博,18-160,Protein A, HRP conjugate
merck millipore,默克密理博,69660,pET-14b DNA - Novagen
merck millipore,默克密理博,250225,Cytochalasin B, Dihydro- - CAS 39156-67-7 - Calbiochem
merck millipore,默克密理博,HTS036M,ChemiSCREEN™ CCR9 Membrane Preparation
merck millipore,默克密理博,04-451,Anti-TRAF6 Antibody, rabbit monoclonal
merck millipore,默克密理博,MAB10139,Anti-LIM Domain Only 2 Antibody, clone 2E6
merck millipore,默克密理博,MABE263,Anti-unmethylated-Histone H3 (Lys9) Antibody, clone 9B1-2G6
